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The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review
- Source :
- International Journal of Reproductive BioMedicine, Vol 15, Iss 1, Pp 1-10 (2017), International Journal of Reproductive Biomedicine, Scopus-Elsevier
- Publication Year :
- 2017
- Publisher :
- Shahid Sadoughi University of Medical Sciences, 2017.
-
Abstract
- Background: D-Aspartic acid (D-Asp) is in invertebrate and vertebrate neuroendocrine tissues, where it carries out important physiological functions. Recently, it has been reported that D-Asp is involved in the synthesis and release of testosterone and is assumed can be used as a testosterone booster for infertile men, and by athletes to increase muscle mass and strength. Objective: The aim of this review is to summarize available evidence related to the effects of D-Asp on serum testosterone levels. Materials and Methods: We conducted a systematic review of all type studies, which evaluated the effect of the D-Asp on blood testosterone including published papers until October 2015, using PubMed, ISI Web of Science, ProQuest and Scopus database. Results: With 396 retrieved records, 23 animal studies and 4 human studies were included. In vivo and in vitro animal studies revealed the effect of D-Asp depending on species, sex and organ-specific. Our results showed that exogenous D-Asp enhances testosterone levels in male animal’s studies, whereas studies in human yielded inconsistent results. The evidence for this association in man is still sparse, mostly because of limited number and poor quality studies. Conclusion: There is an urgent need for more and well-designed human clinical trials with larger sample sizes and longer duration to investigate putative effects of D-Asp on testosterone concentrations.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
lcsh:QH471-489
Biology
lcsh:Gynecology and obstetrics
03 medical and health sciences
Blood testosterone
0302 clinical medicine
D-Aspartic Acid
In vivo
D-Aspartic acid
Internal medicine
medicine
lcsh:Reproduction
Testosterone
Biomedicine
lcsh:RG1-991
business.industry
Obstetrics and Gynecology
Testosterone (patch)
In vitro
Clinical trial
030104 developmental biology
Endocrinology
Reproductive Medicine
Systematic Review
Animal studies
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 24763772 and 24764108
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International Journal of Reproductive BioMedicine
- Accession number :
- edsair.doi.dedup.....3df2c8c26c3e447909653c580b4aa5e8