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UVR-induced G–C to C–G transversions from oxidative DNA damage
- Source :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 571:33-42
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Many oxidizing agents induce G-C to T-A and G-C to C-G transversions, and the frequency largely depends on the oxidative conditions. Guanine is the most oxidizable base among natural bases. The typical oxidative lesion product 8-oxoguanine (8-oxoG) is responsible for G-C to T-A transversion but not for G-C to C-G transversion, and 8-oxoG is more readily oxidized than guanine because of its lowered ionization potential. Recently, imidazolone (Iz), guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) have been demonstrated as oxidative lesion products of guanine and 8-oxoG, which could be responsible for G-C to C-G transversions by forming specific base pair formations.
- Subjects :
- Ultraviolet Rays
Guanine
Base pair
Hydantoins
Health, Toxicology and Mutagenesis
Imidazoles
Oxidative phosphorylation
Oxidative dna damage
Lesion
Oxidative Stress
chemistry.chemical_compound
Biochemistry
chemistry
Genetics
medicine
Animals
Humans
heterocyclic compounds
medicine.symptom
Transversion
Molecular Biology
DNA Damage
Mutagens
Subjects
Details
- ISSN :
- 00275107
- Volume :
- 571
- Database :
- OpenAIRE
- Journal :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- Accession number :
- edsair.doi.dedup.....3dfa1b39429b1b477a61ada601ddeef6