Back to Search
Start Over
miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma
- Source :
- Biochemical and Biophysical Research Communications. 411:586-592
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Recent studies have revealed that microRNA-29c (miR-29c) is involved in a variety of biological processes including carcinogenesis. Here, we report that miR-29c was significantly downregulated in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) cell lines as well as in clinical tissues compared with their corresponding controls. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), a key regulator in inflammation and immunity, was found to be inversely correlated with miR-29c levels and was identified as a target of miR-29c. Overexpression of miR-29c in HepG2.2.15 cells effectively suppressed TNFAIP3 expression and HBV DNA replication as well as inhibited cell proliferation and induced apoptosis. We conclude that miR-29c may play an important role as a tumor suppressive microRNA in the development and progression of HBV-related HCC by targeting TNFAIP3. Thus miR-29c and TNFAIP3 represent key diagnostic markers and potential therapeutic targets for the prevention and treatment of HBV infection.
- Subjects :
- Hepatitis B virus
Carcinoma, Hepatocellular
Biophysics
Down-Regulation
Apoptosis
Biology
Transfection
medicine.disease_cause
Biochemistry
TNFAIP3
Cell Line, Tumor
microRNA
Biomarkers, Tumor
medicine
Humans
Hepatitis B e Antigens
Molecular Biology
Tumor Necrosis Factor alpha-Induced Protein 3
Cell Proliferation
Hepatitis B Surface Antigens
Cell growth
Liver Neoplasms
Intracellular Signaling Peptides and Proteins
Nuclear Proteins
Cell Biology
medicine.disease
digestive system diseases
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
MicroRNAs
Cell Transformation, Neoplastic
Hepatocellular carcinoma
Immunology
Cancer research
Carcinogenesis
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 411
- Database :
- OpenAIRE
- Journal :
- Biochemical and Biophysical Research Communications
- Accession number :
- edsair.doi.dedup.....3e0303826c6ffc37383609f2bc6a1e40