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Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia
- Source :
- Progress in neuro-psychopharmacologybiological psychiatry. 50
- Publication Year :
- 2013
-
Abstract
- Background Genome-wide association studies (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with multifactorial diseases, such as schizophrenia, are significantly more likely to be associated with expression quantitative trait loci (eQTL). It was recently suggested that an immune system imbalance plays an important role in the pathogenesis of schizophrenia. Interleukin-19 is a novel cytokine that may play multiple roles in immune regulation and various diseases. Method We selected eight tag SNPs in the eQTL of the IL-19 gene. Seven of the SNPs are putative cis-acting SNPs. Then, we conducted a case–control study using two independent samples. The first sample comprised 567 schizophrenia patients and 710 controls, and the second sample comprised 677 schizophrenia patients and 667 controls. Result We identified the TGAA haplotype as being significantly associated with schizophrenia (p = 0.0036 and corrected p = 0.0264), although a combined analysis of the TGAA haplotype with the replication samples exhibited a nominally significant difference (p = 0.022 and corrected p = 0.235). Conclusions These results suggest that the IL-19 gene might slightly contribute to the genetic risk of schizophrenia. Thus, further research on the association of eQTL SNPs with schizophrenia is warranted.
- Subjects :
- Adult
Male
Genotype
Quantitative Trait Loci
Single-nucleotide polymorphism
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Asian People
medicine
Humans
Genetic Predisposition to Disease
Gene
Biological Psychiatry
Genetic Association Studies
Genetic association
Pharmacology
Genetics
Interleukins
Haplotype
Middle Aged
medicine.disease
Haplotypes
Schizophrenia
Case-Control Studies
Expression quantitative trait loci
Interleukin 19
Female
Subjects
Details
- ISSN :
- 18784216
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Progress in neuro-psychopharmacologybiological psychiatry
- Accession number :
- edsair.doi.dedup.....3e0843e899b89ae45f261a5e22109c85