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Triclosan: A Widespread Environmental Toxicant with Many Biological Effects
- Source :
- Annual review of pharmacology and toxicology, vol 56, iss 1
- Publication Year :
- 2016
- Publisher :
- eScholarship, University of California, 2016.
-
Abstract
- Triclosan (TCS) is a broad-spectrum antimicrobial agent that has been added to personal care products, including hand soaps and cosmetics, and impregnated in numerous different materials ranging from athletic clothing to food packaging. The constant disposal of TCS into the sewage system is creating a major environmental and public health hazard. Owing to its chemical properties of bioaccumulation and resistance to degradation, TCS is widely detected in various environmental compartments in concentrations ranging from nanograms to micrograms per liter. Epidemiology studies indicate that significant levels of TCS are detected in body fluids in all human age groups. We document here the emerging evidence—from in vitro and in vivo animal studies and environmental toxicology studies—demonstrating that TCS exerts adverse effects on different biological systems through various modes of action. Considering the fact that humans are simultaneously exposed to TCS and many TCS-like chemicals, we speculate that TCS-induced adverse effects may be relevant to human health.
- Subjects :
- 0301 basic medicine
hormone homeostasis
media_common.quotation_subject
Sewage
010501 environmental sciences
Biology
Environment
Toxicology
01 natural sciences
Cosmetics
Medical and Health Sciences
Article
Hazardous Substances
03 medical and health sciences
chemistry.chemical_compound
Anti-Infective Agents
liver pathogenesis
Animals
Humans
antimicrobial resistance
Pharmacology & Pharmacy
0105 earth and related environmental sciences
media_common
environmental hazard
Pharmacology
precautionary principle
business.industry
fungi
Biological Sciences
Antimicrobial
Triclosan
Food packaging
antibacterial
030104 developmental biology
bioaccumulation
chemistry
Environmental chemistry
Bioaccumulation
Environmental toxicology
business
Toxicant
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Annual review of pharmacology and toxicology, vol 56, iss 1
- Accession number :
- edsair.doi.dedup.....3e0d981d7b3c1b619a14edf7e5851aae