Sirtuin 1 aggravates hypertrophic heart failure caused by pressure overload via shifting energy metabolism

Authors :: Tran Ngoc Van Le
Linda Ines Zoungrana
Hao Wang
Mohammad Kasim Fatmi
Di Ren
Meredith Krause-Hauch
Ji Li
Source :: Biochemical and biophysical research communications. 637
Publication Year :: 2022
Abstract: Sirtuin1 (SIRT1) is involved in regulating substrate metabolism in the cardiovascular system. Metabolic homeostasis plays a critical role in hypertrophic heart failure. We hypothesize that cardiac SIRT1 can modulate substrate metabolism during pressure overload-induced heart failure. The inducible cardiomyocyte Sirt1 knockout (icSirt1

Subjects :: Heart Failure
Biophysics
Cell Biology
Aortic Valve Stenosis
Constriction, Pathologic
Hypertrophy
Biochemistry
Mice, Inbred C57BL
Mice
Sirtuin 1
Animals
Myocytes, Cardiac
Energy Metabolism
Molecular Biology

Tools