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Principles of Pharmacotherapy of Seizures and Status Epilepticus
- Source :
- Seminars in neurology. 40(6)
- Publication Year :
- 2020
-
Abstract
- Status epilepticus is a neurological emergency with an outcome that is highly associated with the initial pharmacotherapy management that must be administered in a timely fashion. Beyond first-line therapy of status epilepticus, treatment is not guided by robust evidence. Optimal pharmacotherapy selection for individual patients is essential in the management of seizures and status epilepticus with careful evaluation of pharmacokinetic and pharmacodynamic factors. With the addition of newer antiseizure agents to the market, understanding their role in the management of status epilepticus is critical. Etiology-guided therapy should be considered in certain patients with drug-induced seizures, alcohol withdrawal, or autoimmune encephalitis. Some patient populations warrant special consideration, such as pediatric, pregnant, elderly, and the critically ill. Seizure prophylaxis is indicated in select patients with acute neurological injury and should be limited to the acute postinjury period.
- Subjects :
- Autoimmune encephalitis
medicine.medical_specialty
Neurological injury
business.industry
Critically ill
030208 emergency & critical care medicine
Status epilepticus
Review article
03 medical and health sciences
Benzodiazepines
0302 clinical medicine
Pharmacotherapy
Status Epilepticus
Neurology
Seizures
medicine
Humans
Anticonvulsants
Neurology (clinical)
medicine.symptom
Intensive care medicine
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10989021
- Volume :
- 40
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Seminars in neurology
- Accession number :
- edsair.doi.dedup.....3e2fafd94902dde968f2bb4bbde0d543