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Magnetically Actuated Degradable Microrobots for Actively Controlled Drug Release and Hyperthermia Therapy
- Source :
- Advanced healthcare materials. 8(16)
- Publication Year :
- 2019
-
Abstract
- Microrobots facilitate targeted therapy due to their small size, minimal invasiveness, and precise wireless control. A degradable hyperthermia microrobot (DHM) with a 3D helical structure is developed, enabling actively controlled drug delivery, release, and hyperthermia therapy. The microrobot is made of poly(ethylene glycol) diacrylate (PEGDA) and pentaerythritol triacrylate (PETA) and contains magnetic Fe3 O4 nanoparticles (MNPs) and 5-fluorouracil (5-FU). Its locomotion is remotely and precisely controlled by a rotating magnetic field (RMF) generated by an electromagnetic actuation system. Drug-free DHMs reduce the viability of cancer cells by elevating the temperature under an alternating magnetic field (AMF), a hyperthermic effect. 5-FU is released from the proposed DHMs in normal-, high-burst-, and constant-release modes, controlled by the AMF. Finally, actively controlled drug release from the DHMs in normal- and high-burst-release mode results in a reduction in cell viability. The reduction in cell viability is of greater magnitude in high-burst- than in normal-release mode. In summary, biodegradable DHMs have potential for actively controlled drug release and hyperthermia therapy.
- Subjects :
- Hyperthermia
Materials science
medicine.medical_treatment
Biomedical Engineering
Pharmaceutical Science
Nanoparticle
02 engineering and technology
010402 general chemistry
01 natural sciences
Polyethylene Glycols
Biomaterials
chemistry.chemical_compound
Drug Delivery Systems
medicine
Magnetite Nanoparticles
Wireless control
Hyperthermia, Induced
021001 nanoscience & nanotechnology
medicine.disease
Controlled release
Hyperthermia therapy
0104 chemical sciences
Drug Liberation
chemistry
Acrylates
Propylene Glycols
Drug delivery
Drug release
0210 nano-technology
Ethylene glycol
Biomedical engineering
Subjects
Details
- ISSN :
- 21922659
- Volume :
- 8
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Advanced healthcare materials
- Accession number :
- edsair.doi.dedup.....3e36adc7f7df6c47826da6b6dba6054e