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Ivabradine, coronary artery disease, and heart failure: beyond rhythm control
- Source :
- Drug Design, Development and Therapy, Drug Design, Development and Therapy, Vol 2014, Iss default, Pp 689-700 (2014)
- Publication Year :
- 2014
-
Abstract
- Pietro Scicchitano,1 Francesca Cortese,1 Gabriella Ricci,1 Santa Carbonara,1 Michele Moncelli,1 Massimo Iacoviello,1 Annagrazia Cecere,1 Michele Gesualdo,1 Annapaola Zito,1 Pasquale Caldarola,2 Domenico Scrutinio,3 Rocco Lagioia,3 Graziano Riccioni,4 Marco Matteo Ciccone1 1Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy; 2Section of Cardiovascular Diseases, Policlinic, San Paolo Hospital, Bari, Italy; 3Section of Cardiovascular Diseases, Fondazione Maugeri, Cassano Murge, Italy; 4Intensive Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy Abstract: Elevated heart rate could negatively influence cardiovascular risk in the general population. It can induce and promote the atherosclerotic process by means of several mechanisms involving endothelial shear stress and biochemical activities. Furthermore, elevated heart rate can directly increase heart ischemic conditions because of its skill in unbalancing demand/supply of oxygen and decreasing the diastolic period. Thus, many pharmacological treatments have been proposed in order to reduce heart rate and ameliorate the cardiovascular risk profile of individuals, especially those suffering from coronary artery diseases (CAD) and chronic heart failure (CHF). Ivabradine is the first pure heart rate reductive drug approved and currently used in humans, created in order to selectively reduce sinus node function and to overcome the many side effects of similar pharmacological tools (ie, β-blockers or calcium channel antagonists). The aim of our review is to evaluate the role and the safety of this molecule on CAD and CHF therapeutic strategies. Keywords: chronic heart failure, heart rate reduction, cardiac ischemic disease, heart-rate lowering drugs, funny current
- Subjects :
- medicine.medical_specialty
Population
Diastole
Pharmaceutical Science
Rhythm control
Coronary Artery Disease
Review
Coronary artery disease
Heart Rate
Internal medicine
Drug Discovery
Heart rate
medicine
Animals
Humans
Ivabradine
funny current
education
heart-rate lowering drugs
Pharmacology
Heart Failure
education.field_of_study
business.industry
lcsh:RM1-950
Benzazepines
medicine.disease
chronic heart failure
lcsh:Therapeutics. Pharmacology
heart rate reduction
Heart failure
Cardiology
cardiac ischemic disease
Artery diseases
business
Cardiac ischemic disease
Chronic heart failure
Funny current
Heart rate reduction
Heart-rate lowering drugs
medicine.drug
Subjects
Details
- ISSN :
- 11778881
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Drug design, development and therapy
- Accession number :
- edsair.doi.dedup.....3e3b426ffd02e193115c0ac949f0027e