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Losartan accelerates the repair process of renal fibrosis in UUO mouse after the surgical recanalization by upregulating the expression of Tregs
- Source :
- International Urology and Nephrology. 51:2073-2081
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Obstructive nephropathy is a common cause for chronic kidney disease. Surgery, which is adopted to promptly relieve the obstruction, is the most important method to save damaged kidneys. However, earlier studies have shown that renal function will continue to deteriorate until the terminal stage after the obstruction' relief. The aim of this study is to explore the renal fibrosis and investigate the effect of losartan on renal fibrosis after the obstruction' relief using an improved mouse model of relief for unilateral ureteral obstruction (RUUO). Experiments carried out using C57BL/6 mice (n = 30) were randomly divided into RUUO + Losartan group, RUUO group and sham group. Using an improved mouse RUUO model, this study revealed that the mouse kidney for 3- or 7-day unilateral ureteral obstruction undergoing the RUUO surgery was still in a state of injury and fibrosis, while losartan could effectively ameliorate renal fibrosis by upregulating the expression of CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) in kidney after the surgery of RUUO.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Time Factors
Urology
030232 urology & nephrology
Renal function
Angiotensin-Converting Enzyme Inhibitors
030204 cardiovascular system & hematology
Kidney
urologic and male genital diseases
T-Lymphocytes, Regulatory
Losartan
Mice
Random Allocation
03 medical and health sciences
0302 clinical medicine
Fibrosis
Internal medicine
medicine
Renal fibrosis
Animals
business.industry
medicine.disease
Obstructive Nephropathy
Up-Regulation
Mice, Inbred C57BL
Treatment Outcome
medicine.anatomical_structure
business
Ureteral Obstruction
Kidney disease
medicine.drug
Subjects
Details
- ISSN :
- 15732584 and 03011623
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- International Urology and Nephrology
- Accession number :
- edsair.doi.dedup.....3e45167069e19541a1cdadbb6db2da66