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Oily fish consumption is inversely correlated with cerebral microbleeds in community-dwelling older adults: results from the Atahualpa Project
- Source :
- Aging clinical and experimental research. 28(4)
- Publication Year :
- 2015
-
Abstract
- Oily fish is a major dietary source of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). These nutrients improve endothelial dysfunction, reduce β-amyloid induced damage of neurovascular units, and might prevent the occurrence of cerebral microbleeds. However, this relationship has not been investigated so far. To evaluate the association between oily fish intake and cerebral microbleeds in a population of frequent fish consumers living in coastal Ecuador. Cerebral microbleeds were identified by gradient-echo MRI and oily fish consumption was calculated in community-dwellers aged ≥60 years enrolled in the Atahualpa Project. The association between cerebral microbleeds and fish servings was examined in regression models adjusted for relevant confounders. A predictive model was constructed using quintiles of fish servings to take into account the non-linearity in the relationship. Out of 311 eligible individuals, 293 (94 %) were enrolled. Cerebral microbleeds were recognized in 37 (13 %) individuals. Mean fish consumption was 8.8 ± 5.4 servings per week (ω-3 PUFAs estimates: 10.2 ± 7.1 g). Multivariate analysis showed an inverse relationship between cerebral microbleeds and fish consumption (p
- Subjects :
- Male
Aging
medicine.medical_specialty
Multivariate analysis
Oily fish intake
Population
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Environmental health
Fatty Acids, Omega-3
medicine
Oily fish
Animals
Humans
education
Aged
Cerebral Hemorrhage
chemistry.chemical_classification
Aged, 80 and over
education.field_of_study
business.industry
Confounding
Fishes
Middle Aged
Fish oil
Fish consumption
Surgery
Diet
chemistry
Seafood
Female
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 17208319
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Aging clinical and experimental research
- Accession number :
- edsair.doi.dedup.....3e4ed56085ed44e04cd3ff52ca93b622