ParaStamp and Its Applications to Cell Patterning, Drug Synergy Screening, and Rewritable Devices for Droplet Storage

Engineered materials have been employed as versatile tools to explore fundamental processes in cell biology/drug development as well as an approach towards intelligent devices, thereby becoming key components in modern technology. Herein, a ParaStamp technique is revealed to possess applications for cell patterning, drug screening, and rewritable functional patterning. The ParaStamp includes a micropatterned polydimethylsiloxane master and a liquid-phased paraffin oil generated at high temperature, which can transfer the patterned paramembrane onto varied material surfaces such as glass, polystyrene, and flexible foil. This technique is simple and cost-effective to meet the high-throughput requirement for industries. Taken together, the findings herein should provide general insights in cell biology, biodetection, and the development of smart hydrophobic surfaces.