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Hepatocyte growth factor (HGF) mediates the sustained formation of 1,2-diacylglycerol via phosphatidylcholine-phospholipase C in cultured rat hepatocytes
- Source :
- FEBS letters. 297(3)
- Publication Year :
- 1992
-
Abstract
- The addition of hepatocyte growth factor (HGF) to rat hepatocytes in primary culture resulted in the formation of inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and 1,2-diacylglycerol (DG) by a phosphoinositide-specific phospholipase C (PI-PLC). DG showed a biphasic increase; the first phase, corresponding with the peak of Ins(1,4,5)P3 and a second larger and prolonged phase. The HGF stimulates the phosphatidylcholine (PC)-derived prolonged DG formation by a phospholipase C pathway (PC-PLC) but not by a phospholipase D pathway. HGF also was found to elicit [Ca2+] oscillations which may be associated with the prolonged DG production from PC via the PC-PLC phospholipase C pathway.
- Subjects :
- Male
medicine.medical_specialty
Biophysics
Biology
Biochemistry
Phosphatidylcholine-phospholipase C
Diglycerides
chemistry.chemical_compound
Structural Biology
Internal medicine
Phosphatidylcholine
Genetics
medicine
Animals
Inositol
Diglyceride
Hepatocyte growth factor (HGF)
Growth Substances
Molecular Biology
Cells, Cultured
Diacylglycerol kinase
Sustained DG formation
Phospholipase C
Phospholipase D
Hepatocyte Growth Factor
Rats, Inbred Strains
Cell Biology
Ca2+ oscillation
Molecular biology
Rats
Kinetics
medicine.anatomical_structure
Endocrinology
chemistry
Liver
Hepatocyte
Type C Phospholipases
Phosphatidylcholines
Hepatocyte growth factor
medicine.drug
Signal Transduction
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 297
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- FEBS letters
- Accession number :
- edsair.doi.dedup.....3e833edf5a99a882c6b7a8d868bb7712