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Exploring the course of adolescent anxiety and depression: associations with white matter tract microstructure
- Source :
- EUR ARCH PSY CLIN N. SPRINGER HEIDELBERG, EUR ARCH PSY CLIN N, European Archives of Psychiatry and Clinical Neuroscience. SPRINGER HEIDELBERG, European Archives of Psychiatry and Clinical Neuroscience
- Publication Year :
- 2021
-
Abstract
- Cross-sectional Diffusion Tensor Imaging (DTI) studies have reported alterations in white matter (WM) microstructure in adolescents with internalizing psychopathology. Yet, longitudinal studies investigating the course of WM microstructure are lacking. This study explored WM alterations and its relation to clinical symptoms over time in adolescents with internalizing disorders. DTI scans were acquired at baseline and after three months in 22 adolescents with clinical depression and comorbid anxiety (INT), and 21 healthy peers (HC) (age: 12-18). Tract-based spatial statistics was used for three voxelwise analyses: i) changes in WM microstructure between and within the INT and HC group; ii) associations between changes in symptom severity and changes in WM microstructure within youths with INT; and iii) associations between baseline WM parameters with changes in symptom severity within youths with INT. Data did not reveal changes in WM microstructure between or within groups over three months' time nor associations between changes in WM microstructure and changes in self-reported symptoms (analyses corrected for age, gender and puberty stage). Lower baseline levels of fractional anisotropy (FA) in the right posterior corona radiata (PCR) and right cingulum were associated with a higher decrease of depressive symptoms within the INT group. Post hoc analysis of additional WM parameters in the significant FA clusters showed that higher levels of baseline mean diffusivity and radial diffusivity in the PCR were associated with a lower decrease in depressive symptoms. Baseline WM microstructure characteristics were associated with a higher decrease in depressive symptoms over time. These findings increase our understanding of neurobiological mechanisms underlying the course of internalizing disorders in adolescents.
- Subjects :
- Adolescent
Depression
business.industry
Radial diffusivity
General Medicine
Anxiety Disorders
White matter
Psychiatry and Mental health
Diffusion Tensor Imaging
medicine.anatomical_structure
Fractional anisotropy
Post-hoc analysis
medicine
Adolescent anxiety
Cingulum (brain)
Pharmacology (medical)
Longitudinal Studies
business
Biological Psychiatry
Depression (differential diagnoses)
Diffusion MRI
Clinical psychology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- EUR ARCH PSY CLIN N. SPRINGER HEIDELBERG, EUR ARCH PSY CLIN N, European Archives of Psychiatry and Clinical Neuroscience. SPRINGER HEIDELBERG, European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....3e8aae0fe3ec98216a2680c8b303a414