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Cumulative live birth rates in low-prognosis women

Authors :: Harold R. Verhoeve
Egbert A. Brinkhuis
Simone C Oudshoorn
Marcel H.A van Hooff
Joop S.E. Laven
G.J. Scheffer
Ben W.J. Mol
Jan Bruin
Annemiek W. Nap
Monique H. Mochtar
G. Jur E. Oosterhuis
Marinus J.C. Eijkemans
Ron J. T. van Golde
Theodora C. van Tilborg
Walter K. H. Kuchenbecker
Janet Kwee
Frank J.M. Broekmans
Kathrin Fleischer
Evert J.P. van Santbrink
A. Petra Manger
Annemieke Hoek
Carolien A.M. Koks
Cornelis B. Lambalk
Jori A Leijdekkers
Corry H. Dekoning
Jesper M. J. Smeenk
Madelon van Wely
Helen L. Torrance
Alexander V. Sluijmer
Bendictus C. Schoot
Jaap Friederich
Arie Verhoeff
Henk Groen
Graduate School
Center for Reproductive Medicine
ARD - Amsterdam Reproduction and Development
Amsterdam Reproduction & Development (AR&D)
Obstetrics and gynaecology
ACS - Atherosclerosis & ischemic syndromes
Amsterdam Neuroscience - Cellular & Molecular Mechanisms
Cardiology
Obstetrics & Gynecology
Obstetrie & Gynaecologie
MUMC+: MA Medische Staf Obstetrie Gynaecologie (9)
RS: GROW - R4 - Reproductive and Perinatal Medicine
Reproductive Origins of Adult Health and Disease (ROAHD)
Value, Affordability and Sustainability (VALUE)
Source :: Human reproduction (Oxford, England), 34(6):dez051, 1030-1041. Oxford University Press, Human Reproduction, 34(6), 1030-1041. Oxford University Press, Leijdekkers, J A, Eijkemans, M J C, van Tilborg, T C, Oudshoorn, S C, van Golde, R J T, Hoek, A, Lambalk, C B, de Bruin, J P, Fleischer, K, Mochtar, M H, Kuchenbecker, W K H, Laven, J S E, Mol, B W J, Torrance, H L, Broekmans, F J M, Koks, C A M, Verhoeve, H R, Nap, A W, Scheffer, G J, Manger, A P, Schoot, B C, Oosterhuis, G J E, Sluijmer, A V, Friederich, J, Verhoeff, A, van Hooff, M H A, van Santbrink, E J P, Brinkhuis, E A, Smeenk, J M J, Kwee, J, Dekoning, C H, Groen, H & van Wely, M 2019, ' Cumulative live birth rates in low-prognosis women ', Human Reproduction, vol. 34, no. 6, pp. 1030-1041 . https://doi.org/10.1093/humrep/dez051, Human Reproduction, 34, 1030-1041, Human Reproduction (Oxford, England), Human Reproduction, 34, 6, pp. 1030-1041
Publication Year :: 2019
Abstract: STUDY QUESTION: Do cumulative live birth rates (CLBRs) over multiple IVF/ICSI cycles confirm the low prognosis in women stratified according to the POSEIDON criteria? SUMMARY ANSWER: The CLBR of low-prognosis women is ~56% over 18 months of IVF/ICSI treatment and varies between the POSEIDON groups, which is primarily attributable to the impact of female age. WHAT IS KNOWN ALREADY: The POSEIDON group recently proposed a new stratification for low-prognosis women in IVF/ICSI treatment, with the aim to define more homogenous populations for clinical trials and stimulate a patient-tailored therapeutic approach. These new criteria combine qualitative and quantitative parameters to create four groups of low-prognosis women with supposedly similar biologic characteristics. STUDY DESIGN, SIZE, DURATION: This study analyzed the data of a Dutch multicenter observational cohort study including 551 low-prognosis women, aged