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Carotid Artery Stiffness and Incident Depressive Symptoms: The Paris Prospective Study III
- Source :
- Biological Psychiatry, Biological Psychiatry, Elsevier, 2019, 85, pp.498-505. ⟨10.1016/j.biopsych.2018.09.018⟩, Biological Psychiatry, 85(6), 498-505. Elsevier Science
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- BACKGROUND: Arterial stiffness may contribute to late-life depression via cerebral microvascular damage, but evidence is scarce. No longitudinal study has evaluated the association between arterial stiffness and risk of depressive symptoms. Therefore, we investigated the association between carotid artery stiffness and incident depressive symptoms in a large community-based cohort study.METHODS: This longitudinal study included 7013 participants (mean age 59.7 +/- 6.3 years; 35.8% women) free of depressive symptoms at baseline. Carotid artery stiffness (high-resolution echo tracking) was determined at baseline. Presence of depressive symptoms was determined at baseline and at 4 and 6 years of follow-up, and was defined as a score >= 7 on the validated Questionnaire of Depression, Second Version, Abridged and/or new use of antidepressant medication. Logistic regression and generalized estimating equations were used.RESULTS: In total, 6.9% (n = 484) of the participants had incident depressive symptoms. Individuals in the lowest tertile of carotid distensibility coefficient (indicating greater carotid artery stiffness) compared with those in the highest tertile had a higher risk of incident depressive symptoms (odds ratio: 1.43; 95% confidence interval: 1.10-1.87), after adjustment for age, sex, living alone, education, lifestyle, cardiovascular risk factors, and baseline Questionnaire of Depression, Second Version, Abridged scores. Results were qualitatively similar when we used carotid Young's elastic modulus as a measure of carotid stiffness instead of carotid distensibility coefficient, and when we used generalized estimating equations instead of logistic regression.CONCLUSIONS: Greater carotid stiffness is associated with a higher incidence of depressive symptoms. This supports the hypothesis that carotid stiffness may contribute to the development of late-life depression.
- Subjects :
- Male
0301 basic medicine
Paris
Longitudinal study
medicine.medical_specialty
Aging
Time Factors
Epidemiology
[SDV]Life Sciences [q-bio]
LATE-LIFE DEPRESSION
Logistic regression
03 medical and health sciences
Vascular Stiffness
0302 clinical medicine
SMALL VESSEL DISEASE
Predictive Value of Tests
Risk Factors
Elastic Modulus
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
OLDER-ADULTS
Generalized estimating equation
Biological Psychiatry
POPULATION
RISK
Depression
business.industry
Longitudinal studies
BIPOLAR DISORDER
Odds ratio
MAJOR DEPRESSION
Middle Aged
medicine.disease
Arterial stiffness
Confidence interval
Carotid Arteries
030104 developmental biology
Vascular depression
PULSE-WAVE VELOCITY
Cardiology
Female
HEALTH
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 00063223
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry, Biological Psychiatry, Elsevier, 2019, 85, pp.498-505. ⟨10.1016/j.biopsych.2018.09.018⟩, Biological Psychiatry, 85(6), 498-505. Elsevier Science
- Accession number :
- edsair.doi.dedup.....3eb2f722264af2b129865151c4aa50f8