Back to Search Start Over

Clinical efficiency of combination therapy using testosterone replacement therapy, phosphodiesterase 5 inhibitors and Kampo herbal medicine for eugonadal patients with late‑onset hypogonadism syndrome

Authors :
Hisashi Takeuchi
Hidenori Okubo
Source :
Experimental and Therapeutic Medicine
Publication Year :
2021
Publisher :
Spandidos Publications, 2021.

Abstract

In the present study, the initial treatment efficiency of combination therapy using testosterone replacement therapy (TRT), herbal medicine and phosphodiesterase 5 inhibitors (PDE5i) in male patients with late-onset hypogonadism (LOH) were assessed. A total of 21 patients were enrolled and after 12 weeks, the clinical efficacy was evaluated based on improvement of LOH symptoms via laboratory parameters and several questionnaires, including the Ageing Males' Symptoms (AMS) scale. The overall AMS scores, as well as the psychological, physical and sexual AMS factors prior to and after treatment in the TRT, testosterone enanthate (T enanthate) monotherapy and T enanthate + PDE5i treatment groups were significantly improved. In the herbal medicine group, only the AMS physiological factors were significantly improved after treatment compared with the baseline. The improvement of the overall AMS scores, as well as the physiological and sexual AMS factors, were significantly negatively correlated with the free testosterone (FT) value prior to treatment. In conclusion, treatment with combination therapy using TRT, herbal medicine and PDE5i improved AMS scores in patients with LOH syndrome. Particularly in patients with LOH syndrome and low FT, the symptoms were significantly improved following combination therapy.

Details

ISSN :
17921015 and 17920981
Volume :
22
Database :
OpenAIRE
Journal :
Experimental and Therapeutic Medicine
Accession number :
edsair.doi.dedup.....3eb9ea41be024349da3eb1b3b2d094d6
Full Text :
https://doi.org/10.3892/etm.2021.10608