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PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide
- Source :
- Cell Death & Disease, Cell Death and Disease, Vol 10, Iss 3, Pp 1-12 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group UK, 2019.
-
Abstract
- Melanoma is one of the most aggressive skin cancers worldwide. Although there has been much effort toward improving treatment options over the past few years, there remains an urgent need for effective therapy. Immunotherapy combined with chemotherapy has shown great promise in clinical trials. Here, we studied the cooperative effects of the small molecule drug pimozide, which has a therapeutic effect in melanoma, and RNA interference (RNAi) targeting PD-1, an important immune checkpoint molecule involved in tumor immune escape. PD-1 siRNA was delivered by attenuated Salmonella to melanoma-bearing mice in combination with pimozide. Our results demonstrated that the combination therapy had the optimal therapeutic effect on melanoma. The mechanisms underlying the efficacy involved the induction of apoptosis and an enhanced immune response. This study suggests that immunotherapy based on PD-1 inhibition combined with anticancer drugs could be a promising clinical strategy for the treatment of melanoma.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Skin Neoplasms
Combination therapy
medicine.medical_treatment
T-Lymphocytes
Immunology
Programmed Cell Death 1 Receptor
Transplantation, Heterologous
Melanoma, Experimental
Antineoplastic Agents
Apoptosis
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
Mice
0302 clinical medicine
Immune system
Pimozide
RNA interference
Salmonella
medicine
Animals
lcsh:QH573-671
RNA, Small Interfering
lcsh:Cytology
business.industry
Melanoma
Cell Biology
Immunotherapy
medicine.disease
Combined Modality Therapy
Immune checkpoint
Transplantation
Mice, Inbred C57BL
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
RNA Interference
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20414889
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cell Death & Disease
- Accession number :
- edsair.doi.dedup.....3ec1a23040dcb53bde23490a48f39cf1