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Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass
- Source :
- Calcified Tissue International. 103:638-652
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Peroxisome proliferator-activated receptor-gamma coactivator (PGC1α) is a transcription coactivator that interacts with a broad range of transcription factors involved in several biological responses. Here, we show that PGC1α plays a role in skeletal homeostasis since aged PGC1α-deficient mice (PGC1α−/−) display impaired bone structure. Micro-CT of the tibial mid-shaft showed a marked decrease of cortical thickness in PGC1α−/− (− 11.9%, p
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Osteocalcin
030209 endocrinology & metabolism
Bone and Bones
Bone resorption
Bone remodeling
Mice
03 medical and health sciences
Peroxisome proliferator-activated receptor-gamma coactivator
0302 clinical medicine
Endocrinology
Bone Density
Osteoclast
Internal medicine
Coactivator
Settore MED/33 - Malattie Apparato Locomotore
medicine
Animals
Orthopedics and Sports Medicine
Bone
Mice, Knockout
biology
Chemistry
Osteoblast
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Mitochondria
030104 developmental biology
medicine.anatomical_structure
biology.protein
Female
Cortical bone
Bone marrow
Type I collagen
Subjects
Details
- ISSN :
- 14320827 and 0171967X
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Calcified Tissue International
- Accession number :
- edsair.doi.dedup.....3ec878b99e64d150856cd5bb0c6f2fe3