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Synergistic effects of fructose and glucose on lipoprotein risk factors for cardiovascular disease in young adults
- Source :
- Metabolism
- Publication Year :
- 2020
-
Abstract
- BackgroundFructose consumption increases risk factors for cardiometabolic disease. It is assumed that the effects of free sugars on risk factors are less potent because they contain less fructose. We compared the effects of consuming fructose, glucose or their combination, high fructose corn syrup (HFCS), on cardiometabolic risk factors.MethodsAdults (18-40 years; BMI 18-35 kg/m2) participated in a parallel, double-blinded dietary intervention during which beverages sweetened with aspartame, glucose (25% of energy requirements (ereq)), fructose or HFCS (25% and 17.5% ereq) were consumed for two weeks. Groups were matched for sex, baseline BMI and plasma lipid/lipoprotein concentrations. 24-h serial blood samples were collected at baseline and at the end of intervention. Primary outcomes were 24-h triglyceride AUC, LDL-cholesterol (C), and apolipoprotein (apo)B. Interactions between fructose and glucose were assessed post hoc.Findings145 subjects (26.0 ± 5.8 years; body mass index 25.0 ± 3.7 kg/m2) completed the study. As expected, the increase of 24-h triglycerides compared with aspartame was highest during fructose consumption (25%: 6.66 mmol/Lx24h 95% CI [1.90 to 11.63], P = 0.0013 versus aspartame), intermediate during HFCS consumption (25%: 4.68 mmol/Lx24h 95% CI [-0.18 to 9.55], P = 0.066 versus aspartame) and lowest during glucose consumption. In contrast, the increase of LDL-C was highest during HFCS consumption (25%: 0.46 mmol/L 95% CI [0.16 to 0.77], P = 0.0002 versus aspartame) and intermediate during fructose consumption (25%: 0.33 mmol/L 95% CI [0.03 to 0.63], P = 0.023 versus aspartame), as was the increase of apoB (HFCS-25%: 0.108 g/L 95%CI [0.032 to 0.184], P = 0.001; fructose 25%: 0.072 g/L 95%CI [-0.004 to 0.148], P = 0.074 versus aspartame). The post hoc analyses showed significant interactive effects of fructose*glucose on LDL-C and apoB (both P
- Subjects :
- Male
0301 basic medicine
Apolipoprotein B
Endocrinology, Diabetes and Metabolism
Cardiovascular
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Medicine
Aspartame
chemistry.chemical_classification
biology
Dietary intervention trial
Cholesterol
Heart Disease
Female
Adult
medicine.medical_specialty
Interaction
Adolescent
Lipoproteins
Clinical Sciences
Free sugar
030209 endocrinology & metabolism
Fructose
Article
LDL
Endocrinology & Metabolism
Young Adult
03 medical and health sciences
Clinical Research
Internal medicine
Humans
Monosaccharide
Triglycerides
Nutrition
Triglyceride
business.industry
High-fructose corn syrup
Prevention
Cholesterol, LDL
Glucose
030104 developmental biology
chemistry
Heart Disease Risk Factors
biology.protein
business
Lipoprotein
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Metabolism
- Accession number :
- edsair.doi.dedup.....3ecf919ceeb1a31f3aeeea5a8139d43d