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Intact Dendritic Cell Pathogen-Recognition Receptor Functions Associate with Chronic Hepatitis C Treatment-Induced Viral Clearance
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 7, p e102605 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science, 2014.
-
Abstract
- Although studies have addressed the exhaustion of the host's immune response to HCV and its role in treatment, there is little information about the possible contribution of innate immunity to treatment-induced clearance. We hypothesized that because intact myeloid dendritic cell (MDC) pathogen sensing functions are associated with improved HCV-specific CD8+ T cell functionality in some chronically infected patients, it might enhance HCV clearance rate under standard interferon therapy. To investigate this hypothesis, TLR-induced MDC activation and HCV-specific CD8+ T cell response quality were monitored longitudinally at the single-cell level using polychromatic flow cytometry in chronically infected patients undergoing interferon therapy. We correlated the immunological, biochemical and virological data with response to treatment. We demonstrate that the clinical efficacy of interferon-induced viral clearance is influenced by the extent to which HCV inhibits MDC functions before treatment, rather than solely on a breakdown of the extrinsic T cell immunosuppressive environment. Thus, viral inhibition of MDC functions before treatment emerges as a co-determining factor in the clinical efficacy of interferon therapy during chronic HCV infection.
- Subjects :
- Male
Viral Diseases
Gastroenterology and hepatology
lcsh:Medicine
Hepacivirus
CD8-Positive T-Lymphocytes
medicine.disease_cause
Lymphocyte Activation
Virus Replication
Biochemistry
Immune Receptors
Hepatitis
Polyethylene Glycols
0302 clinical medicine
Animal Cells
Cytotoxic T cell
Myeloid Cells
lcsh:Science
Toll-like Receptors
0303 health sciences
Multidisciplinary
Immune System Proteins
Cytokine Therapy
Middle Aged
Hepatitis C
Recombinant Proteins
3. Good health
Infectious hepatitis
medicine.anatomical_structure
Infectious Diseases
Receptors, Pattern Recognition
030211 gastroenterology & hepatology
Drug Therapy, Combination
Female
Cellular Types
Research Article
Signal Transduction
Adult
T cell
Hepatitis C virus
Immune Cells
Immunology
Antigen-Presenting Cells
Interferon alpha-2
Antiviral Agents
03 medical and health sciences
Immune system
Ribavirin
medicine
Humans
Immunity to Infections
Liver diseases
030304 developmental biology
Immune Evasion
Medicine and health sciences
Innate immune system
business.industry
lcsh:R
Biology and Life Sciences
Proteins
Interferon-alpha
Dendritic cell
Cell Biology
Dendritic Cells
Hepatitis C, Chronic
Immunity, Innate
lcsh:Q
business
Pattern Recognition Receptors
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3edf1c3d5671ad828c42dec0eb77ec57