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An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls
- Source :
- International Journal of Environmental Research and Public Health, Volume 16, Issue 15, International Journal of Environmental Research and Public Health, Vol 16, Iss 15, p 2786 (2019)
- Publication Year :
- 2019
-
Abstract
- Maternal exposure to polychlorinated biphenyls (PCBs) results in abnormal fetal development, possibly because of epigenetic alterations. However, the association between PCB levels in cord serum with fetal DNA methylation status in cord tissue is unclear. This study aims to identify alterations in DNA methylation in cord tissue potentially associated with PCB levels in cord serum from a birth cohort in Chiba, Japan (male neonates = 32, female neonates = 43). Methylation array analysis identified five sites for female neonates (cg09878117, cg06154002, cg06289566, cg12838902, cg01083397) and one site for male neonates (cg13368805) that demonstrated a change in the methylation degree. This result was validated by pyrosequencing analysis, showing that cg06154002 (tudor domain containing 9: TDRD9) in cord tissue from female neonates is significantly correlated with total PCB levels in cord serum. These results indicate that exposure to PCBs may alter TDRD9 methylation levels, although this hypothesis requires further validation using data obtained from female neonates. However, since the present cohort is small, further studies with larger cohorts are required to obtain more data on the effects of PCB exposure and to identify corresponding biomarkers.
- Subjects :
- Male
Cord
Health, Toxicology and Mutagenesis
lcsh:Medicine
Physiology
010501 environmental sciences
01 natural sciences
Umbilical cord
Article
Umbilical Cord
Cohort Studies
Fetal Development
03 medical and health sciences
chemistry.chemical_compound
Japan
Medicine
Humans
Epigenetics
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
Fetus
DNA methylation
business.industry
lcsh:R
Public Health, Environmental and Occupational Health
DNA Helicases
Infant, Newborn
Polychlorinated biphenyl
birth cohort
Methylation
Fetal Blood
Polychlorinated Biphenyls
medicine.anatomical_structure
chemistry
Maternal Exposure
Cohort
Female
business
Biomarkers
polychlorinated biphenyl
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 16
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- International journal of environmental research and public health
- Accession number :
- edsair.doi.dedup.....3edf80074b3bcde50c3939d1cd8b4ef2