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An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls

Authors :
Shino Nishizawa-Jotaki
Hiromi Tanabe
Atsushi Kaneda
Akifumi Eguchi
Bahityar Rahmutulla
Hidenobu Miyaso
Chisato Mori
Kenichi Sakurai
Emiko Todaka
Masahiro Watanabe
Source :
International Journal of Environmental Research and Public Health, Volume 16, Issue 15, International Journal of Environmental Research and Public Health, Vol 16, Iss 15, p 2786 (2019)
Publication Year :
2019

Abstract

Maternal exposure to polychlorinated biphenyls (PCBs) results in abnormal fetal development, possibly because of epigenetic alterations. However, the association between PCB levels in cord serum with fetal DNA methylation status in cord tissue is unclear. This study aims to identify alterations in DNA methylation in cord tissue potentially associated with PCB levels in cord serum from a birth cohort in Chiba, Japan (male neonates = 32, female neonates = 43). Methylation array analysis identified five sites for female neonates (cg09878117, cg06154002, cg06289566, cg12838902, cg01083397) and one site for male neonates (cg13368805) that demonstrated a change in the methylation degree. This result was validated by pyrosequencing analysis, showing that cg06154002 (tudor domain containing 9: TDRD9) in cord tissue from female neonates is significantly correlated with total PCB levels in cord serum. These results indicate that exposure to PCBs may alter TDRD9 methylation levels, although this hypothesis requires further validation using data obtained from female neonates. However, since the present cohort is small, further studies with larger cohorts are required to obtain more data on the effects of PCB exposure and to identify corresponding biomarkers.

Details

ISSN :
16604601
Volume :
16
Issue :
15
Database :
OpenAIRE
Journal :
International journal of environmental research and public health
Accession number :
edsair.doi.dedup.....3edf80074b3bcde50c3939d1cd8b4ef2