Back to Search
Start Over
Predictors of Biological Age: The Implications for Wellness and Aging Research
Predictors of Biological Age: The Implications for Wellness and Aging Research
- Source :
- Gerontology and Geriatric Medicine, Vol 7 (2021), Gerontology and Geriatric Medicine
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- As healthspan and lifespan research breakthroughs have become more commonplace, the need for valid, practical markers of biological age is becoming increasingly paramount. The accessibility and affordability of biological age predictors that can reveal information about mortality and morbidity risk, as well as remaining years of life, has profound clinical and research implications. In this review, we examine 5 groups of aging biomarkers capable of providing accurate biological age estimations. The unique capabilities of these biomarkers have far reaching implications for the testing of both pharmaceutical and non-pharmaceutical interventions designed to slow or reverse biological aging. Additionally, the enhanced validity and availability of these tools may have increasingly relevant clinical value. The authors of this review explore those implications, with an emphasis on lifestyle modification research, and provide an overview of the current evidence regarding 5 biological age predictor categories: Telomere length, composite biomarkers, DNA methylation “epigenetic clocks,” transcriptional predictors of biological age, and functional age predictors.
- Subjects :
- Gerontology
biogerontology
business.industry
Morbidity risk
Biological age
aging
RC952-954.6
Psychological intervention
Review Article
frailty
cellular processes
chronic diseases
Lifestyle modification
Geriatrics
Clinical value
Medicine
genetics
cardiovascular diseases and risk
Geriatrics and Gerontology
business
Subjects
Details
- ISSN :
- 23337214
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Gerontology and Geriatric Medicine
- Accession number :
- edsair.doi.dedup.....3ee6d04e77384caa324e268ea77364d4
- Full Text :
- https://doi.org/10.1177/23337214211046419