Inadequacy of tissue microarrays for the immunohistochemical detection of cancer stem cells in solid tumors: a viewpoint

Pathology Unit, Istituto Nazionale Tumori Fondazione “G. Pascale”, via Mariano Semmola 80131, Napoli, Italy “Recent acquisitions on human carcinogenesis suggest that small populations of tumor stem cells can influence and modify neoplastic cells behavior and aggressiveness, as well as therapeutic response. In fact, the presence of cancer stem cells niches results in a poor sensitivity to current chemotherapy treatments.”