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Efficacy and functionality of silver-coated textiles in patients with atopic eczema
Efficacy and functionality of silver-coated textiles in patients with atopic eczema
- Source :
- Journal of the European Academy of Dermatology and Venereology. 20:534-541
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Background Microbial skin colonization with Staphylococcus aureus is known to play an important role in atopic eczema (AE). Recently, an antibacterial effect of silver-coated textiles on S. aureus colonization has been demonstrated. Objectives To investigate clinical efficacy and functionality of silver-coated textiles in AE, a multicentre, double-blind, placebo-controlled trial was conducted. Patients/methods From November 2001 to August 2002, 68 consecutive outpatients clinically diagnosed with generalized AE were included in the study. Inclusion criteria were the clinical diagnosis of AE with a moderate severity as measured by the scoring of atopic dermatitis (SCORAD) index with at least 20. Patients were instructed to wear either silver-coated (verum, 35 patients + 2 dropouts) or cotton garments (placebo, 22 patients + 9 dropouts) directly on the skin for 2 weeks. Only basic skin care and ongoing therapy with topical steroids or oral antihistamines was permitted. Clinical severity was assessed using the ‘SCORAD’ before, during and at the end of study. Quality of life (QOL), wearing comfort (WC) and functionality (FU) of study clothes were measured in parallel. Patients documented their subjective and objective symptoms daily. Results In the verum group, eczema improved significantly after 1 week with further enhancement until the end of study ( P = 0.03 and P < 0.001). Silver-coated textiles were comparable to cotton in WC and FU. Pruritus and self-assigned skin condition improved significantly more than with placebo ( P < 0.001 and P = 0.003). Conclusions In conclusion, silver-coated textiles are able to improve objective and subjective symptoms of AE significantly within 2 weeks, showing a good wearing comfort and functionality comparable to cotton.
- Subjects :
- Male
medicine.medical_specialty
Silver
Adolescent
Dermatology
Placebo
Severity of Illness Index
Statistics, Nonparametric
Dermatitis, Atopic
law.invention
Anti-Infective Agents
Double-Blind Method
Randomized controlled trial
Quality of life
law
Internal medicine
Severity of illness
medicine
Humans
Prospective Studies
SCORAD
Prospective cohort study
Chi-Square Distribution
medicine.diagnostic_test
business.industry
Textiles
Atopic dermatitis
medicine.disease
Surgery
Treatment Outcome
Infectious Diseases
Quality of Life
Female
business
Chi-squared distribution
Subjects
Details
- ISSN :
- 14683083 and 09269959
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of the European Academy of Dermatology and Venereology
- Accession number :
- edsair.doi.dedup.....3f45d94ecdbd9e135ee10e56857dbb50
- Full Text :
- https://doi.org/10.1111/j.1468-3083.2006.01526.x