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Clinical and pathological findings of acute zinc intoxication in a puppy
- Source :
- Scopus-Elsevier
- Publication Year :
- 2002
-
Abstract
- This report describes the clinical and pathological findings in a case of acute zinc poisoning in a young dog. The puppy suffered four days of progressively more severe vomiting and diarrhoea. Jaundice and pale mucous membranes, severe haematemesis and haemoglobinuria were other findings. Despite intensive therapy, the dog died a few hours after hospitalisation. Postmortem examination revealed a metallic foreign body in the stomach, catarrhal gastritis, hepatomegaly and enlarged, dark kidneys. Histology showed hepatic centrilobular vacuolar degeneration, haemoglobinuric nephrosis with early tubular necrosis, haemosiderosis and extramedullary haematopoiesis, as well as neuronal damage. The foreign body was mainly composed of zinc. Plasma zinc values were markedly raised (34.5 microg/ml; normal range 0.8 to 1.0 microg/ml). Pathophysiological mechanisms of zinc poisoning are discussed.
- Subjects :
- Diarrhea
Male
Pathology
medicine.medical_specialty
Vomiting
Diagnosis, Differential
Death, Sudden
Dogs
Puppy
Animals, Dog Disease
biology.animal
Dog
Medicine
Animals
Dog Diseases
Small Animals
Pathological
biology
business.industry
Animal
Stomach
Foreign-Body Reaction
Poisoning
Histology
Jaundice
medicine.disease
Pathophysiology
Radiography
Zinc
medicine.anatomical_structure
Animals, Newborn
medicine.symptom
Foreign body
business
Subjects
Details
- ISSN :
- 00224510
- Volume :
- 43
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of small animal practice
- Accession number :
- edsair.doi.dedup.....3f4a7de7e67453d78d3f568fc50ef73f