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Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium
- Source :
- Human Genetics, Li, Q, Wojciechowski, R, Simpson, C L, Hysi, P G, Verhoeven, V J M, Ikram, M K, Höhn, R, Vitart, V, Hewitt, A W, Oexle, K, Mäkelä, K-M, MacGregor, S, Pirastu, M, Fan, Q, Cheng, C-Y, St Pourcain, B, McMahon, G, Kemp, J P, Northstone, K, Rahi, J S, Cumberland, P M, Martin, N G, Sanfilippo, P G, Lu, Y, Wang, Y X, Hayward, C, Polašek, O, Campbell, H, Bencic, G, Wright, A F, Wedenoja, J, Zeller, T, Schillert, A, Mirshahi, A, Lackner, K, Yip, S P, Yap, M K H, Ried, J S, Gieger, C, Murgia, F, Wilson, J F, Fleck, B, Yazar, S, Vingerling, J R, Hofman, A, Uitterlinden, A, Rivadeneira, F, Amin, N & Karssen, L & Oostra, B A 2015, ' Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error : the CREAM consortium ', Human Genetics, vol. 134, no. 2, pp. 131-146 . https://doi.org/10.1007/s00439-014-1500-y, Human Genetics, 134(2), 131-146. Springer-Verlag, Hum. Genet. 134, 131-146 (2015)
- Publication Year :
- 2015
-
Abstract
- To identify genetic variants associated with refractive astigmatism in the general population, meta-analyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged
- Subjects :
- Male
Refractive error
BLUE MOUNTAINS EYE
CORNEAL ASTIGMATISM
Spherical equivalent
Genome-wide association study
astigmatism
gene
SNP
DISEASE
Cohort Studies
0302 clinical medicine
Statistics
Genetics(clinical)
Neural Cell Adhesion Molecules
POPULATION
Genetics (clinical)
Original Investigation
Genetics
0303 health sciences
education.field_of_study
Age Factors
High Mobility Group Proteins
Middle Aged
3142 Public health care science, environmental and occupational health
3. Good health
Female
OPEN-ANGLE GLAUCOMA
Adult
Genetic Markers
EXPERIMENTALLY-INDUCED MYOPIA
Keratoconus
SUSCEPTIBILITY LOCI
Cell Adhesion Molecules, Neuronal
education
Population
Nerve Tissue Proteins
Astigmatism
Biology
White People
03 medical and health sciences
AGE
Asian People
MAJOR LOCUS
medicine
Humans
3125 Otorhinolaryngology, ophthalmology
030304 developmental biology
Genetic association
Calcium-Binding Proteins
Heritability
medicine.disease
NONCODING RNAS
030221 ophthalmology & optometry
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 03406717
- Database :
- OpenAIRE
- Journal :
- Human Genetics, Li, Q, Wojciechowski, R, Simpson, C L, Hysi, P G, Verhoeven, V J M, Ikram, M K, Höhn, R, Vitart, V, Hewitt, A W, Oexle, K, Mäkelä, K-M, MacGregor, S, Pirastu, M, Fan, Q, Cheng, C-Y, St Pourcain, B, McMahon, G, Kemp, J P, Northstone, K, Rahi, J S, Cumberland, P M, Martin, N G, Sanfilippo, P G, Lu, Y, Wang, Y X, Hayward, C, Polašek, O, Campbell, H, Bencic, G, Wright, A F, Wedenoja, J, Zeller, T, Schillert, A, Mirshahi, A, Lackner, K, Yip, S P, Yap, M K H, Ried, J S, Gieger, C, Murgia, F, Wilson, J F, Fleck, B, Yazar, S, Vingerling, J R, Hofman, A, Uitterlinden, A, Rivadeneira, F, Amin, N & Karssen, L & Oostra, B A 2015, ' Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error : the CREAM consortium ', Human Genetics, vol. 134, no. 2, pp. 131-146 . https://doi.org/10.1007/s00439-014-1500-y, Human Genetics, 134(2), 131-146. Springer-Verlag, Hum. Genet. 134, 131-146 (2015)
- Accession number :
- edsair.doi.dedup.....3f4ead522ca1569d34e02a146a6a111f
- Full Text :
- https://doi.org/10.1007/s00439-014-1500-y