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How Well Do Children with Cystic Fibrosis Sleep? An Actigraphic and Questionnaire-Based Study
- Source :
- The Journal of Pediatrics. 182:170-176
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- To measure sleep patterns and quality, objectively and subjectively, in clinically stable children with cystic fibrosis (CF) and healthy control children, and to examine the relationship between sleep quality and disease severity.Clinically stable children with CF and healthy control children (7-18 years of age) were recruited. Sleep patterns and quality were measured at home with actigraphy (14 days). Overnight peripheral capillary oxygen saturation was measured via the use of pulse oximetry. Daytime sleepiness was evaluated by the Pediatric Daytime Sleepiness Scale (PDSS) and subjective sleep quality by the Sleep Disturbance Scale for Children and Obstructive Sleep Apnea-18.A total of 87 children with CF and 55 control children were recruited with no differences in age or sex. Children with CF had significantly lower total sleep time and sleep efficiency than control children due to frequent awakenings and more wake after sleep onset. In children with CF, forced expiratory volume in 1 second and overnight peripheral capillary oxygen saturation nadir correlated positively with total sleep time and sleep efficiency and negatively with frequency of awakenings and wake after sleep onset. Patients with CF had significantly greater Sleep Disturbance Scale for Children (45 vs 35; P .001), Obstructive Sleep Apnea-18 (35 vs 24; P .001), and PDSS scores (14 vs 11; P .001). There was a negative correlation between PDSS and forced expiratory volume in 1 second (r = -0.23; P .05).Even in periods of clinical stability, children with CF get less sleep than their peers due to more time in wakefulness during the night rather than less time spent in bed. Objective measures of sleep disturbance and subjective daytime sleepiness were related to disease severity. In contrast, parents of children with CF report high levels of sleep disturbance unrelated to disease severity.
- Subjects :
- Male
Sleep Wake Disorders
medicine.medical_specialty
Pediatrics
Adolescent
Cystic Fibrosis
Polysomnography
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric
Tertiary Care Centers
03 medical and health sciences
Age Distribution
0302 clinical medicine
Reference Values
Forced Expiratory Volume
Surveys and Questionnaires
medicine
Humans
Oximetry
Sex Distribution
Child
Sleep disorder
medicine.diagnostic_test
Pulmonary Gas Exchange
business.industry
Incidence
Australia
Actigraphy
Prognosis
medicine.disease
Sleep in non-human animals
Obstructive sleep apnea
Pulse oximetry
030228 respiratory system
Case-Control Studies
Pediatrics, Perinatology and Child Health
Physical therapy
Female
Sleep onset
business
Body mass index
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00223476
- Volume :
- 182
- Database :
- OpenAIRE
- Journal :
- The Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....3f5aa1867d25e12464fc486b76b98543