Lower frequency of <scp>MDSCs</scp> was significantly related to functional cure in <scp>CHB</scp> patients treated with peginterferon

Myeloid-derived suppressor cells (MDSCs) and CD4Flow cytometry analysis was performed along with longitudinal immune monitoring of 97 hepatitis B e antigen (HBeAg) negative chronic hepatitis B (CHB) patients receiving PegIFNα-2a weekly for 48 weeks.The frequencies of mMDSCs and CD4These results suggest that a poor response to PegIFNα-2a treatment in CHB patients may be related to the frequencies of immune suppressive cells, while the therapeutic targeting of these cells might be effective in boosting anti-HBV immunity.