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Age-related brain structural alterations as an intermediate phenotype of psychosis
- Source :
- Dukart, J, Fusar-Poli, P, Smieskova, R, Harrisberger, F, Lenz, C, Schmidt, A, Walter, A, Huber, C G, Riecher-Roessler, A, Simon, A, Lang, U E & Borgwardt, S J 2017, ' Age-related brain structural alterations as an intermediate phenotype of psychosis ', Journal of Psychiatry and Neuroscience, vol. 42, no. 5, pp. 307-319 . https://doi.org/10.1503/jpn.160179
- Publication Year :
- 2017
-
Abstract
- Background: There is only limited agreement with respect to location, directionality and functional implications of brain structural alterations observed in patients with schizophrenia. Additionally, their link to occurrence of psychotic symptoms remains unclear. A viable way of addressing these questions is to examine populations in an at-risk mental state (ARMS) before the transition to psychosis. Methods: We tested for structural brain alterations in individuals in an ARMS compared with healthy controls and patients with first-episode psychosis (FEP) using voxel-based morphometry and measures of cortical thickness. Furthermore, we evaluated if these alterations were modified by age and whether they were linked to the observed clinical symptoms. Results: Our sample included 59 individuals with ARMS, 26 healthy controls and 59 patients with FEP. We found increased grey matter volume and cortical thickness in individuals with ARMS and a similar pattern of structural alterations in patients with FEP. We further found stronger age-related reductions in grey matter volume and cortical thickness in both patients with FEP and individuals with ARMS, linking these alterations to observed clinical symptoms. Limitations: The ARMS group comprised subgroups with heterogeneous levels of psychosis risk and medication status. Furthermore, the cross-sectional nature of our study and the reduced number of older patients limit conclusions with respect to observed interactions with age. Conclusion: Our findings on consistent structural alterations in individuals with ARMS and patients with FEP and their link to clinical symptoms have major implications for understanding their time of occurrence and relevance to psychotic symptoms. Interactions with age found for these alterations may explain the heterogeneity of findings reported in the literature.
- Subjects :
- Oncology
medicine.medical_specialty
Psychosis
medicine.diagnostic_test
Cross-sectional study
business.industry
Magnetic resonance imaging
Grey matter
medicine.disease
030227 psychiatry
03 medical and health sciences
Psychiatry and Mental health
0302 clinical medicine
medicine.anatomical_structure
Schizophrenia
Age related
Internal medicine
medicine
Pharmacology (medical)
Young adult
business
030217 neurology & neurosurgery
Biological Psychiatry
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Dukart, J, Fusar-Poli, P, Smieskova, R, Harrisberger, F, Lenz, C, Schmidt, A, Walter, A, Huber, C G, Riecher-Roessler, A, Simon, A, Lang, U E & Borgwardt, S J 2017, ' Age-related brain structural alterations as an intermediate phenotype of psychosis ', Journal of Psychiatry and Neuroscience, vol. 42, no. 5, pp. 307-319 . https://doi.org/10.1503/jpn.160179
- Accession number :
- edsair.doi.dedup.....3f800f67a5440a03788f3be903095ab2
- Full Text :
- https://doi.org/10.1503/jpn.160179