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The role of the chorda tympani nerve in the activation of the rat hypothalamic histaminergic system by leptin
- Source :
- Neuroscience letters. 300(2)
- Publication Year :
- 2001
-
Abstract
- A possible pathway through which leptin activates the histaminergic system was studied using in vivo microdialysis in rats. Intraperitoneal injection of leptin (1.3 mg/kg) caused a significant increase in hypothalamic histamine release, however, its intracerebroventricular injection (10 microg/rat) did not cause any significant changes in the release. Furthermore, leptin (1.3 mg/kg) had no effect on histamine release in rats whose chorda tympani nerves, a branch of the facial nerve which mediates taste information, were transected bilaterally. These findings indicate that leptin activates the histaminergic system by the peripheral signal inputs via the chorda tympani resulting in the suppression of food intake.
- Subjects :
- Leptin
Male
medicine.medical_specialty
Microdialysis
medicine.medical_treatment
Central nervous system
Intraperitoneal injection
Hypothalamus
Biology
chemistry.chemical_compound
stomatognathic system
Internal medicine
Neural Pathways
medicine
Animals
Rats, Wistar
Neurons
Appetite Regulation
General Neuroscience
digestive, oral, and skin physiology
Histaminergic
Taste Buds
Facial nerve
Denervation
Rats
Endocrinology
medicine.anatomical_structure
chemistry
Taste
sense organs
Chorda Tympani Nerve
Histamine
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 300
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....3f8bef43b40fd9c080f4bfb394cdce2b