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The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer
- Source :
- Seminars in Cancer Biology. 60:57-71
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in a plethora of tumors. More recent evidence indicates additional contribution of these transporters to other processes, such as tumor cell dissemination and metastasis, thereby extending their possible roles in tumor progression. While the role of some ABC transporters, such as ABCB1, ABCC1 and ABCG2, in multidrug resistance is well documented, the mechanisms by which ABC transporters affect the proliferation, differentiation, migration and invasion of cancer cells are still poorly defined and are frequently controversial. This review, summarizes recent advances that highlight the role of subfamily A members in cancer. Emerging evidence highlights the potential value of ABCA members as biomarkers of risk and response in different tumors, but information is disperse and very little is known about their possible mechanisms of action. The only clear evidence is that ABCA members are involved in lipid metabolism and homeostasis. In particular, the relationship between ABCA1 and cholesterol is becoming evident in different fields of biology, including cancer. In parallel, emerging findings indicate that cholesterol, the main component of cell membranes, can influence many physiological and pathological processes, including cell migration, cancer progression and metastasis. This review aims to link the dispersed knowledge regarding the relationship of ABCA members with lipid metabolism and cancer in an effort to stimulate and guide readers to areas that the writers consider to have significant impact and relevant potentialities.
- Subjects :
- 0301 basic medicine
Cancer Research
ATP Binding Cassette Transporter, Subfamily A
Abcg2
Antineoplastic Agents
ATP-binding cassette transporter
Bioinformatics
Metastasis
Structure-Activity Relationship
03 medical and health sciences
0302 clinical medicine
Cell Line, Tumor
Neoplasms
medicine
Animals
Humans
biology
Cancer
Cell migration
medicine.disease
Drug Resistance, Multiple
030104 developmental biology
Gene Expression Regulation
Organ Specificity
Tumor progression
Multigene Family
030220 oncology & carcinogenesis
ABCA1
Cancer cell
biology.protein
Subjects
Details
- ISSN :
- 1044579X
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Seminars in Cancer Biology
- Accession number :
- edsair.doi.dedup.....3f90a923d7e9cbc204d763851657888e