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ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes
- Source :
- Redox Biology, Vol 37, Iss, Pp 101696-(2020), Redox Biology
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases, inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress, regulate metabolic pathways and initiate proliferation, inflammation and cell death responses remain poorly characterized. In this analytic review, we concluded that: 1) Based on different features and functions, eleven types of ROS can be classified into seven functional groups: metabolic stress-sensing, chemical connecting, organelle communication, stress branch-out, inflammasome-activating, dual functions and triple functions ROS. 2) Among the ROS generation systems, mitochondria consume the most amount of oxygen; and nine types of ROS are generated; thus, mitochondrial ROS systems serve as the central hub for connecting ROS with inflammasome activation, trained immunity and immunometabolic pathways. 3) Increased nuclear ROS production significantly promotes cell death in comparison to that in other organelles. Nuclear ROS systems serve as a convergent hub and decision-makers to connect unbearable and alarming metabolic stresses to inflammation and cell death. 4) Balanced ROS levels indicate physiological homeostasis of various metabolic processes in subcellular organelles and cytosol, while imbalanced ROS levels present alarms for pathological organelle stresses in metabolic processes. Based on these analyses, we propose a working model that ROS systems are a new integrated network for sensing homeostasis and alarming stress in metabolic processes in various subcellular organelles. Our model provides novel insights on the roles of the ROS systems in bridging metabolic stress to inflammation, cell death and tumorigenesis; and provide novel therapeutic targets for treating those diseases. (Word count: 246).
- Subjects :
- 0301 basic medicine
Mitochondrial ROS
Programmed cell death
Clinical Biochemistry
Review Article
Trained immunity
Mitochondrion
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
A sensing network for metabolic stress
Organelle
medicine
Homeostasis
lcsh:QH301-705.5
Cell Nucleus
chemistry.chemical_classification
Inflammation
Reactive oxygen species
lcsh:R5-920
Organic Chemistry
Reactive oxygen species (ROS)
Inflammasome
Mitochondria
Cell biology
Nuclear signaling
Cytosol
Metabolic pathway
030104 developmental biology
chemistry
lcsh:Biology (General)
Reactive Oxygen Species
lcsh:Medicine (General)
030217 neurology & neurosurgery
Signal Transduction
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....3fa650645aa818812a17532265cd3e5e