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Nonalcoholic fatty liver disease and eGFR levels could be linked by the PNPLA3 I148M polymorphism in children with obesity
- Source :
- Pediatric obesityREFERENCES. 14(10)
- Publication Year :
- 2019
-
Abstract
- Background: PNPLA3 I148M polymorphism has an effect on modulation of estimated glomerular filtration rate (eGFR) in nonobese nondiabetic adults and in children with histologically confirmed nonalcoholic fatty liver disease (NAFLD). Objectives: The objective of the study is to explore the impact of PNPLA3 I148M polymorphism on eGFR in children with obesity with and without NAFLD. Methods: We genotyped 591 patients with obesity for PNPLA3 I148M polymorphism. Anthropometrical, biochemical, and instrumental data were collected. NAFLD was defined by the presence of ultrasound-detected liver steatosis and/or ALT levels greater than 40 IU/L. Results: Patients with NAFLD showed significantly lower eGFR levels compared with subjects without NAFLD. Children with PNPLA3 MM genotype showed lower eGFR levels compared with those with either PNPLA3 IM or II genotypes both in the presence and absence of NAFLD. A general linear model for eGFR variance, including gender, duration of obesity, PNPLA3 genotypes, HOMA, BMI-SDS, LDL-C, and triglycerides as covariates, confirmed an inverse association between eGFR and PNPLA3 genotype only in the presence of NAFLD. Conclusions: Children with obesity and PNPLA3 MM genotype show lower eGFR levels compared with other genotypes, with a major effect of this polymorphism in the presence of NAFLD.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Adolescent
Genotype
Renal function
030209 endocrinology & metabolism
digestive system
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Liver steatosis
children
Polymorphism (computer science)
Non-alcoholic Fatty Liver Disease
Internal medicine
NAFLD
Nonalcoholic fatty liver disease
medicine
Humans
Obesity
Child
PNPLA3
030109 nutrition & dietetics
Nutrition and Dietetics
Polymorphism, Genetic
business.industry
Health Policy
renal function
Public Health, Environmental and Occupational Health
nutritional and metabolic diseases
Membrane Proteins
Lipase
medicine.disease
digestive system diseases
Pediatrics, Perinatology and Child Health
Female
business
chronic kidney disease
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 20476310
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Pediatric obesityREFERENCES
- Accession number :
- edsair.doi.dedup.....3fbb2679983a88081da271a19e664555