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Phosphate binding by sucroferric oxyhydroxide ameliorates renal injury in the remnant kidney model
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group UK, 2019.
-
Abstract
- Recent clinical studies indicate that the disturbed phosphate metabolism in chronic kidney disease (CKD) may facilitate kidney injury; nonetheless, the causal role of phosphate in CKD progression remains to be elucidated. Here, we show that intestinal phosphate binding by sucroferric oxyhydroxide (SF) ameliorates renal injury in the rat remnant kidney model. Sprague-Dawley rats received 5/6 nephrectomy (RK) and had a normal chow or the same diet containing SF (RK + SF). RK rats showed increased plasma FGF23 and phosphate levels, which were suppressed by SF administration. Of note, albuminuria in RK rats was significantly ameliorated by SF at both 4 and 8 weeks. SF also attenuated glomerulosclerosis and tubulointerstitial injury. Moreover, several different approaches confirmed the protective effects on podocytes, explaining the attenuation of glomerulosclerosis and albuminuria observed in this study. As a possible mechanism, we found that SF attenuated renal inflammation and fibrosis in RK rats. Interestingly, von Kossa staining of the kidney revealed calcium phosphate deposition in neither RK nor RK + SF rats; however, plasma levels of calciprotein particles were significantly reduced by SF. These data indicate that latent positive phosphate balance accelerates CKD progression from early stages, even when overt ectopic calcification is absent.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Sucrose
medicine.medical_treatment
Biopsy
lcsh:Medicine
Ferric Compounds
Article
Phosphates
03 medical and health sciences
Ectopic calcification
chemistry.chemical_compound
0302 clinical medicine
Fibrosis
Internal medicine
medicine
Animals
Renal Insufficiency, Chronic
lcsh:Science
Kidney
Multidisciplinary
Glomerulosclerosis, Focal Segmental
Podocytes
lcsh:R
Glomerulosclerosis
medicine.disease
Phosphate
Immunohistochemistry
Nephrectomy
Rats
Disease Models, Animal
Drug Combinations
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Albuminuria
lcsh:Q
Disease Susceptibility
medicine.symptom
030217 neurology & neurosurgery
Biomarkers
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....3fc23d2b8424be6df9a7e7a82c28c83a