Back to Search
Start Over
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
- Source :
- NATURE GENETICS, Nature Genetics, Nature Genetics, Nature Publishing Group, 2019, 51 (1), pp.51-62. ⟨10.1038/s41588-018-0303-9⟩, Nature Genetics, 51(1), 51, Nature genetics, 51(1), 51-62. Nature Publishing Group, Nature Genetics, 51(1), 51-62. Nature Publishing Group, Giri, A, Hellwege, J N, Keaton, J M, Park, J, Qiu, C, Warren, H R, Torstenson, E S, Kovesdy, C P, Sun, Y V, Wilson, O D, Robinson-Cohen, C, Roumie, C L, Chung, C P, Birdwell, K A, Damrauer, S M, DuVall, S L, Klarin, D, Cho, K, Wang, Y, Evangelou, E, Cabrera, C P, Wain, L V, Shrestha, R, Mautz, B S, Akwo, E A, Sargurupremraj, M, Debette, S, Boehnke, M, Scott, L J, Luan, J, Zhao, J-H, Willems, S M, Thériault, S, Shah, N, Oldmeadow, C, Almgren, P, Li-Gao, R, Verweij, N, Boutin, T S, Mangino, M, Ntalla, I, Feofanova, E, Surendran, P, Cook, J P, Richardson, T G, Zeggini, E, Scott, R A, Palmer, C N A & Timpson, N J & Wilson, P W F 2019, ' Trans-ethnic association study of blood pressure determinants in over 750,000 individuals ', Nature Genetics, vol. 51, no. 1, pp. 51-62 . https://doi.org/10.1038/s41588-018-0303-9
- Publication Year :
- 2019
-
Abstract
- International audience; In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
- Subjects :
- Male
LOCI
Gene Expression
Physiology
Blood Pressure
Genome-wide association study
IDENTIFIES 8
Mice
0302 clinical medicine
Ethnicity
PARTITIONING HERITABILITY
Genetics & Heredity
0303 health sciences
Kidney
Blood Pressure-International Consortium of Exome Chip Studies
Million Veteran Program
PULSE PRESSURE
11 Medical And Health Sciences
Middle Aged
Up-Regulation
3. Good health
Pulse pressure
Kidney Tubules
medicine.anatomical_structure
VINTAGE
International Consortium for Blood Pressure
AUTOSOMAL-DOMINANT HYPERTENSION
Female
Life Sciences & Biomedicine
Understanding Society Scientific Group
Adolescent
Diastole
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
03 medical and health sciences
Genetics
medicine
Animals
Humans
GENOME-WIDE ASSOCIATION
Gene
030304 developmental biology
Genetic association
Science & Technology
06 Biological Sciences
GLOBAL BURDEN
MEAN ARTERIAL
GENE
Blood pressure
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
SOLUBLE GUANYLYL CYCLASE
Transcriptome
030217 neurology & neurosurgery
Genome-Wide Association Study
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- NATURE GENETICS, Nature Genetics, Nature Genetics, Nature Publishing Group, 2019, 51 (1), pp.51-62. ⟨10.1038/s41588-018-0303-9⟩, Nature Genetics, 51(1), 51, Nature genetics, 51(1), 51-62. Nature Publishing Group, Nature Genetics, 51(1), 51-62. Nature Publishing Group, Giri, A, Hellwege, J N, Keaton, J M, Park, J, Qiu, C, Warren, H R, Torstenson, E S, Kovesdy, C P, Sun, Y V, Wilson, O D, Robinson-Cohen, C, Roumie, C L, Chung, C P, Birdwell, K A, Damrauer, S M, DuVall, S L, Klarin, D, Cho, K, Wang, Y, Evangelou, E, Cabrera, C P, Wain, L V, Shrestha, R, Mautz, B S, Akwo, E A, Sargurupremraj, M, Debette, S, Boehnke, M, Scott, L J, Luan, J, Zhao, J-H, Willems, S M, Thériault, S, Shah, N, Oldmeadow, C, Almgren, P, Li-Gao, R, Verweij, N, Boutin, T S, Mangino, M, Ntalla, I, Feofanova, E, Surendran, P, Cook, J P, Richardson, T G, Zeggini, E, Scott, R A, Palmer, C N A & Timpson, N J & Wilson, P W F 2019, ' Trans-ethnic association study of blood pressure determinants in over 750,000 individuals ', Nature Genetics, vol. 51, no. 1, pp. 51-62 . https://doi.org/10.1038/s41588-018-0303-9
- Accession number :
- edsair.doi.dedup.....3fc65101b526e49b26bca973f7ee89ec