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Are children with SARS‐CoV‐2 infection at high risk for thrombosis? Viscoelastic testing and coagulation profiles in a case series of pediatric patients
- Source :
- Pediatric Blood & Cancer
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The coagulopathy of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well documented in adults, with increases in D-dimer and prothrombin time found to be strong predictors of mortality, and anticoagulation shown to decrease this mortality. Viscoelastic parameters such as elevations in maximum clot firmness (MCF) on rotational thromboelastometry (ROTEM) have correlated with a hypercoagulable state in adults with SARS-CoV-2. We report our experience in children infected with SARS-CoV-2, with noted elevations in D-dimer and MCF on ROTEM (indicating hypercoagulability). Exploration of viscoelastic testing to provide additional laboratory-based evidence for pediatric-specific risk assessment for thromboprophylaxis in SARS-CoV-2 is warranted.
- Subjects :
- medicine.medical_specialty
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Coagulopathy
Medicine
Pediatrics, Perinatology, and Child Health
skin and connective tissue diseases
Prothrombin time
medicine.diagnostic_test
business.industry
fungi
virus diseases
Hematology
medicine.disease
Thrombosis
body regions
Thromboelastometry
Coagulation
Oncology
030220 oncology & carcinogenesis
Pediatrics, Perinatology and Child Health
Maximum clot firmness
business
Risk assessment
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 15455017 and 15455009
- Database :
- OpenAIRE
- Journal :
- Pediatric Blood & Cancer
- Accession number :
- edsair.doi.dedup.....3fd6e383c80f213d621e3a051be28131
- Full Text :
- https://doi.org/10.1002/pbc.28737