Back to Search
Start Over
Multidisciplinary treatment of esophageal cancer: The role of active surveillance after neoadjuvant chemoradiation
- Source :
- Annals of Gastroenterological Surgery, Vol 4, Iss 4, Pp 352-359 (2020), Annals of Gastroenterological Surgery, Annals of Gastroenterological Surgery, 4(4), 352-359. Wiley-Blackwell Publishing Ltd
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The optimal treatment of esophageal cancer is still controversial. Neoadjuvant chemoradiotherapy followed by radical esophagectomy is a standard treatment. Morbidity after esophagectomy however is still considerable and has an impact on patients' quality of life. Given a pathologic complete response rate of approximately 30% in patients after neoadjuvant chemoradiation followed by surgery, active surveillance has been introduced as a new alternative approach. Active surveillance involves regular clinical response evaluations in patients after neoadjuvant therapy to detect residual or recurrent disease. As long as there is no suspicion of disease activity, surgery is withheld. Esophagectomy is reserved for patients presenting with an incomplete response or resectable recurrent disease. Active surveillance after neoadjuvant treatment has been previously applied in other types of malignancy with encouraging results. This paper discusses its role in esophageal cancer.<br />Morbidity after esophagectomy is still considerable and has an impact on patients' quality of life. Given a pathologic complete response rate of approximately 30% in patients after neoadjuvant chemoradiation followed by surgery, active surveillance is currently under investigation as a new alternative approach.
- Subjects :
- medicine.medical_specialty
RD1-811
salvage surgery
medicine.medical_treatment
Review Article
RC799-869
Malignancy
SDG 3 - Good Health and Well-being
Quality of life
Multidisciplinary approach
medicine
Recurrent disease
esophageal cancer
neoadjuvant chemoradiation
Review Articles
Neoadjuvant therapy
business.industry
Standard treatment
active surveillance
Gastroenterology
Diseases of the digestive system. Gastroenterology
Esophageal cancer
medicine.disease
Esophagectomy
Surgery
Radiology
business
Subjects
Details
- ISSN :
- 24750328
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Annals of Gastroenterological Surgery
- Accession number :
- edsair.doi.dedup.....3fd9e2d124036e7e3ffd53a1159df99f