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The role of sexual networks in studies of how BV and STIs increase the risk of subsequent reinfection
- Source :
- Epidemiology and Infection. 146:2003-2009
- Publication Year :
- 2018
- Publisher :
- Cambridge University Press (CUP), 2018.
-
Abstract
- Prior studies have demonstrated that both bacterial vaginosis (BV) and sexually transmitted infections (STIs) are strong independent risk factors for subsequent STI. In observational studies of this biological enhancement (BE) hypothesis, it is important to adjust for the risk of STI exposure so that the independent effect of BE can be assessed. We sought to model if two markers of local sexual network (partner concurrency and cumulative number of STIs) represented residual confounding in the models of risk for subsequent infection in a study that screened 3620 women for STIs every 3 months for a year. Mixed-effects logistic regression was used to calculate the odds ratios for an incident diagnosis ofChlamydia trachomatis,Neisseria gonorrhoeae,Trichomonas vaginalisand BV following a diagnosis of any of these four at the prior visit, controlling for the cumulative number of STIs and partner concurrency variables. We found that partner concurrency and cumulative number of STIs were each associated with incident infection, and in general, controlling for these variables reduced the strength of the association between prior and incident infections. We conclude that the frequently found association between prior and incident STIs is associated with both BE and sexual network structure.
- Subjects :
- Adult
Sexual network
Epidemiology
Sexual Behavior
urologic and male genital diseases
medicine.disease_cause
Logistic regression
Risk Assessment
Gonorrhea
Young Adult
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Longitudinal Studies
030212 general & internal medicine
Original Paper
030505 public health
Chlamydia
business.industry
Incidence
Confounding
Vaginosis, Bacterial
Odds ratio
Chlamydia Infections
medicine.disease
female genital diseases and pregnancy complications
Sexual Partners
Infectious Diseases
Female
Trichomonas vaginalis
Bacterial vaginosis
Trichomonas Vaginitis
0305 other medical science
Chlamydia trachomatis
business
Demography
Subjects
Details
- ISSN :
- 14694409 and 09502688
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Epidemiology and Infection
- Accession number :
- edsair.doi.dedup.....3fe01bd0dd235b1958fcb5e2a0f9e4b9