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Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study
- Source :
- Diabetes & Metabolism Journal, Diabetes & Metabolism Journal, Vol 45, Iss 5, Pp 675-683 (2021)
- Publication Year :
- 2021
- Publisher :
- Korean Diabetes Association, 2021.
-
Abstract
- Background Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM). Methods From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated. Results In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, −1.1%±1.2%; P
- Subjects :
- Blood Glucose
Drug
medicine.medical_specialty
Combination therapy
Drug/Regimen
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
medicine.medical_treatment
Drug therapy, combination
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Diseases of the endocrine glands. Clinical endocrinology
Injections
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
medicine
Insulin
Humans
Hypoglycemic Agents
Retrospective Studies
media_common
Glycated Hemoglobin
business.industry
Type 2 Diabetes Mellitus
Retrospective cohort study
RC648-665
medicine.disease
Regimen
Diabetes Mellitus, Type 2
Oral hypoglycemic agents
Original Article
business
Subjects
Details
- ISSN :
- 22336087 and 22336079
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism Journal
- Accession number :
- edsair.doi.dedup.....3fece27bdda9558bd7bf6f04777a10da