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Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study

Authors :
Dong Jin Chung
Young Sang Lyu
Tae Sun Park
In Joo Kim
Jun Sung Moon
Young Il Kim
Heung Yong Jin
Eonju Jeon
Ju Hyung Lee
Eun Sook Kim
Seung Min Chung
Sang Soo Kim
Sung Woo Kim
Jung Eun Jang
Tae Nyun Kim
Jin Ook Chung
Nan Hee Cho
Sunghwan Suh
Kyu Chang Won
Chang Won Lee
Duk Kyu Kim
Hye Soon Kim
Jeong Mi Kim
Hosang Shon
Min Hee Jang
Sang Yong Kim
Il Seong Nam-Goong
Dong Hyeok Cho
Kyung Ae Lee
Jin Hwa Kim
Mi-Kyung Kim
Source :
Diabetes & Metabolism Journal, Diabetes & Metabolism Journal, Vol 45, Iss 5, Pp 675-683 (2021)
Publication Year :
2021
Publisher :
Korean Diabetes Association, 2021.

Abstract

Background Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM). Methods From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated. Results In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, −1.1%±1.2%; P

Details

ISSN :
22336087 and 22336079
Volume :
45
Database :
OpenAIRE
Journal :
Diabetes & Metabolism Journal
Accession number :
edsair.doi.dedup.....3fece27bdda9558bd7bf6f04777a10da