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Antiemetic prophylaxis in patients undergoing hematopoietic stem cell transplantation: a multicenter survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programs
- Publication Year :
- 2020
-
Abstract
- A survey within hematopoietic stem cell transplant (HSCT) centers of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) was performed in order to describe current antiemetic prophylaxis in patients undergoing HSCT. The multicenter survey was performed by a questionnaire, covering the main areas on chemotherapy-induced nausea and vomiting (CINV): antiemetic prophylaxis guidelines used, antiemetic prophylaxis in different conditioning regimens, and methods of CINV evaluation. The survey was carried out in November 2016, and it was repeated 6 months after the publication of the Multinational Association of Supportive Care in Cancer (MASCC)/European Society for Medical Oncology (ESMO) specific guidelines on antiemetic prophylaxis in HSCT. The results show a remarkable heterogeneity of prophylaxis among the various centers and a significant difference between the guidelines and the clinical practice. In the main conditioning regimens, the combination of a serotonin3 receptor antagonist (5-HT3-RA) with dexamethasone and neurokin1 receptor antagonist (NK1-RA), as recommended by MASCC/ESMO guidelines, increased from 0 to 15% (before the publication of the guidelines) to 9–30% (after the publication of the guidelines). This study shows a lack of compliance with specific antiemetic guidelines, resulting mainly in under-prophylaxis. Concerted strategies are required to improve the current CINV prophylaxis, to draft shared common guidelines, and to increase the knowledge and the adherence to the current recommendations for CINV prophylaxis in the specific field of HSCT.
- Subjects :
- medicine.medical_specialty
Antiemetic Agent
Transplantation Conditioning
medicine.drug_class
Vomiting
CINV
Practice Patterns
Transplantation, Autologous
03 medical and health sciences
0302 clinical medicine
Antiemetic prophylaxis
Hematopoietic stem cell transplantation
MASCC/ESMO guidelines
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Medicine
Antiemetic
Humans
Statistics & numerical data
Practice Patterns, Physicians'
Aprepitant
Transplantation
Physicians'
business.industry
Hematopoietic Stem Cell Transplantation
Nausea
Hematology
General Medicine
Myeloablative Agonists
Allografts
Clinical trial
Italy
030220 oncology & carcinogenesis
Health Care Surveys
Practice Guidelines as Topic
Antiemetics
Guideline Adherence
business
Autologous
030215 immunology
Chemotherapy-induced nausea and vomiting
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3ff17b46f87b7fa3807f9b7dbf842001