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A New Method for Chemoselective Conjugation of Unprotected Peptides to Dauno- and Doxorubicin
- Source :
- Bioorganic & Medicinal Chemistry Letters. 11:1343-1346
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- A new approach for chemoselective ligation of peptides to dauno- and doxorubicin through an oxime bond is presented. The method does not require protecting groups on the peptide moiety.
- Subjects :
- Daunorubicin
Stereochemistry
Molecular Sequence Data
Clinical Biochemistry
Pharmaceutical Science
Antineoplastic Agents
Peptide
Tripeptide
Biochemistry
Chemical synthesis
Structure-Activity Relationship
chemistry.chemical_compound
Drug Delivery Systems
Drug Discovery
medicine
Moiety
Doxorubicin
Amino Acid Sequence
Molecular Biology
chemistry.chemical_classification
Chemistry
Organic Chemistry
Hydrogen-Ion Concentration
Oxime
Molecular Medicine
Peptides
Drug carrier
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....4022d423d209963354d4ec1fd096d378
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00223-2