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Long-term vitamin-K antagonist use and coronary artery calcification
- Publication Year :
- 2020
-
Abstract
- Background The aim of this study was to investigate the impact of vitamin K antagonist (VKA) therapy on coronary artery calcification (CAC) by comparing long-term VKA users with metallic prosthetic valves (MPVs) and VKA-free patients undergoing coronary calcium scoring for cardiovascular (CV) risk stratification. Methods A total of 108 patients (43 VKA users with MPV and 65 gender-, age-, and risk-factor-matched VKA-free patients) were included in the study. CAC was determined via computed tomography (CT) and quantified on the basis of the Agatston score. The VKA group comprised patients who had an MPV for longer than 5 years, which entailed long-term VKA use. Results Long-term VKA users had more calcified coronary arteries compared with the control group (178.1 +/- 278 vs. 61.1 +/- 130.6,p= 0.01). There was no difference between groups in terms of traditional CV risk factors. The mean duration of VKA use was 15 +/- 7 years for the patients with MPV. There was no correlation between the duration of VKA use and mean Agatston score (r= 0.2,p= 0.215). Conclusion With its unique selection of patient groups, our study extends the findings of previous research that long-term VKA use is related to CAC as detected via CT scanning. The longer and more potent VKA regimen required for MPV patients is the primary cause of CAC in this group.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Computed tomography
Coronary calcium
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Vascular Calcification
medicine.diagnostic_test
business.industry
Vitamins
Vitamin K antagonist
Coronary Vessels
Coronary arteries
Regimen
medicine.anatomical_structure
Coronary artery calcification
Cardiology
Cardiology and Cardiovascular Medicine
business
Agatston score
Tomography, X-Ray Computed
Artery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....402bdb6591e3c0894af340cd63fcb845