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A biocompatible cobaltporphyrin-based complex micelle constructed via supramolecular assembly for oxygen transfer
- Source :
- Biomaterials Science. 4:857-862
- Publication Year :
- 2016
- Publisher :
- Royal Society of Chemistry (RSC), 2016.
-
Abstract
- Herein, a complex micelle as an oxygen nano-carrier is constructed through the hierarchical assembly of the diblock copolymer poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLys), tetrakis(4-sulfonatophenyl)porphinato cobalt(ii) (Co(ii)TPPS), a heptapeptide (Cys-His-His-His-His-His-His) and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD). Co(ii)TPPS was encapsulated into the cavities of TM-β-CDs driven by the host-guest interaction so that the irreversible formation of a μ-oxo-dimer of Co(ii)TPPS can be effectively prevented. The imidazole groups of the heptapeptide were selected as good axial ligands coordinating to the centric cobalt of Co(ii)TPPS, which subtly constituted the five-coordinated precursor serving as an active functional centre for oxygen binding. The sixth position of Co(ii)TPPS can bind oxygen. Furthermore, the host-guest inclusion (TM-β-CD/Co(ii)TPPS) was loaded into the hydrophobic core of the complex micelle and tightly fixed with PLys chains. The hydrophilic PEG blocks stretched in the aqueous solution constitute the shells which stabilize the structure of the complex micelle as well as impart the complex micelle sufficient blood circulation time. Moreover, the complex micelle exhibited excellent biocompatibility and cellular uptake. Therefore, the rationally designed amphiphilic structure can work as promising artificial O2 carriers in vivo. Potentially, the complex micelle can be expected to change the anaerobic microenvironment and find applications in the repair of the cells damaged by cellular hypoxia.
- Subjects :
- Metalloporphyrins
Stereochemistry
Biomedical Engineering
Biocompatible Materials
Beta-Cyclodextrins
02 engineering and technology
010402 general chemistry
01 natural sciences
Micelle
Polyethylene Glycols
Supramolecular assembly
chemistry.chemical_compound
Amphiphile
Polymer chemistry
Humans
General Materials Science
Particle Size
Micelles
Drug Carriers
Photosensitizing Agents
Singlet Oxygen
Singlet oxygen
Lysine
beta-Cyclodextrins
Hep G2 Cells
021001 nanoscience & nanotechnology
Cell Hypoxia
0104 chemical sciences
Oxygen
chemistry
Nanoparticles
0210 nano-technology
Drug carrier
Hydrophobic and Hydrophilic Interactions
Ethylene glycol
Oxygen binding
Subjects
Details
- ISSN :
- 20474849 and 20474830
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Biomaterials Science
- Accession number :
- edsair.doi.dedup.....4030d7fb0b26ea4a80eabf9ace77ca4e