Back to Search
Start Over
Outcomes and Treatment of Lumbosacral Spinal Tuberculosis: A Retrospective Study of 53 Patients
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 6, p e0130185 (2015)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science, 2015.
-
Abstract
- Study Strategy A retrospective clinic study. Purpose To evaluate the efficacy of conservative and surgical treatment for lumbosacral tuberculosis. Methods This study retrospectively reviewed 53 patients with lumbosacral tuberculosis who were treated in our institution between January 2005 and January 2011. There were 29 males and 24 females with average ages of 37.53 ± 17.28 years (range 6–72 years). 11 patients were given only anti-TB drugs; the remainder underwent anterior debridement, interbody fusion with and without instrumentation, or one-stage anterior debridement combined with posterior instrumentation. Outcome data for these patients included neurologic status, lumbosacral angle, erythrocyte sedimentation rate value(ESR) and C-reactive protein value(CRP) were assessed before and after treatment. Results The mean lumbosacral angles were 23.00°± 2.90°in the conservatively treated patients and 22.36°± 3.92o in the surgically treated patients. At the final follow-up, this had improved to 24.10o ± 2.96°in the conservatively treated patients and 28.13° ± 1.93°in the surgically treated patients (all P < 0.05). There were statistically significant differences before and after treatment in terms of ESR and CRP (all P < 0.05). All patients achieved bone fusion. The mean follow-up period was 32.34 ± 8.13 months (range 18 to 55 months). The neurological deficit did not worsen in any of the patients. Conclusions It has been proven that conservative and surgical treatments are safe and effective and produce good clinical outcomes for patients with lumbosacral tuberculosis. The advantages of operation include thoroughness of debridement, decompression of the spinal cord, and adequate spinal stabilization.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sacrum
Adolescent
Decompression
medicine.medical_treatment
Antitubercular Agents
lcsh:Medicine
Lumbar vertebrae
Blood Sedimentation
Young Adult
medicine
Back pain
Animals
Humans
lcsh:Science
Child
Aged
Retrospective Studies
Multidisciplinary
Lumbar Vertebrae
medicine.diagnostic_test
business.industry
lcsh:R
Retrospective cohort study
Middle Aged
Decompression, Surgical
Surgery
Radiography
medicine.anatomical_structure
C-Reactive Protein
Spinal Fusion
Treatment Outcome
Debridement
Back Pain
Spinal fusion
Erythrocyte sedimentation rate
Lumbosacral angle
lcsh:Q
Female
Tuberculosis, Spinal
medicine.symptom
business
Lumbosacral joint
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....4038a86219faf356956aef5f623c99b6