Development of a New Solid-Phase Extraction Base Method for Free Saccharide Content Estimation of Meningococcal Conjugate Vaccines

Authors :: Riccardo De Ricco
Francesca Rech
Valeria Onnis
Salvatore Sanna Coccone
Giusy Scalia
Cristina Marcozzi
Massimiliano Gavini
Sara Beni
Sara Giannini
Luca Nompari
Chiara Parlati
Claudia Magagnoli
Simona Cianetti
Francesco Berti
Source :: ACS Omega. 7:39875-39883
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.
Abstract: GlaxoSmithKline (GSK) is currently developing a fully liquid presentation to ease the administration of the licensed quadrivalent conjugate vaccine (Menveo) against meningococcal serogroup A, C, W, and Y (MenACWY) infections. Herein, we report a new method for determining the free saccharide (FS) content of CRM

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