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Angucycline antibiotics and its derivatives from marine-derived actinomycete Streptomyces sp. A6H
- Source :
- Natural product research. 30(22)
- Publication Year :
- 2016
-
Abstract
- Vineomycin A1 (1) and B2 (2) were isolated from the culture broth of marine actinomycete Streptomyces sp. A6H. Five hydrolysis products were obtained by rational hydrolysis and methanolysis of the fermentation extract. Their structures were characterised as aquayamycin (3), vineomycinone B2 (4), 9-C-D-olivosyltetrangulol (5), 7-O-methylgaltamycinone (6) and vineomycinone B2 methyl ester (7). In addition to these compounds, two ester derivatives, vineolactone A (8) and vineomycinone B2 benzyl ester (9) of compound 4 were generated semisynthetically. Compound 6 is a new analogue of galtamycinone, while compounds 8 and 9 are new members of vineomycins. Cytotoxic activities and antimicrobial activities were determined for all compounds. The results indicate that only compound 1 showed significant activities with IC50 value of 0.34 μM against H1975 and MIC value of 4 μg/mL against Staphylococcus aureus.
- Subjects :
- Aquayamycin
biology
010405 organic chemistry
Stereochemistry
medicine.drug_class
Organic Chemistry
Antibiotics
Plant Science
biology.organism_classification
medicine.disease_cause
Antimicrobial
01 natural sciences
Biochemistry
Streptomyces
Semisynthesis
Combinatorial chemistry
0104 chemical sciences
Analytical Chemistry
010404 medicinal & biomolecular chemistry
Hydrolysis
chemistry.chemical_compound
chemistry
Staphylococcus aureus
medicine
Fermentation
Subjects
Details
- ISSN :
- 14786427
- Volume :
- 30
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Natural product research
- Accession number :
- edsair.doi.dedup.....404f3260939e13f343d5418b4059d499