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Evaluation of serum cysteine-rich protein 61 levels in patients with coronary artery disease
- Source :
- Biomarkers in medicine. 12(4)
- Publication Year :
- 2018
-
Abstract
- Aim: The aim is to evaluate serum cysteine-rich protein 61 (Cyr61) levels in patients with coronary artery disease (CAD). Patients & methods: Serum Cyr61 levels were measured in 180 patients with CAD and 74 participants without CAD. Results: Serum Cyr61 levels were significantly higher in CAD patients. Patients with acute coronary syndrome showed significantly higher Cyr61 than those with stable angina pectoris. Serum Cyr61 levels in complex lesion group were significantly higher. Serum Cyr61 was positively correlated with Gensini score and C-reactive protein. Multivariable logistic regression analyses demonstrated that serum Cyr61 levels were independently correlated with the existence of CAD (p = 0.01). Conclusion: Our study suggested Cyr61 as a potential biomarker in characterizing CAD and therapeutic target for CAD.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Acute coronary syndrome
Clinical Biochemistry
Inflammation
CAD
Coronary Artery Disease
030204 cardiovascular system & hematology
Logistic regression
Gastroenterology
Cysteine rich protein
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Drug Discovery
medicine
Humans
In patient
cardiovascular diseases
biology
business.industry
Biochemistry (medical)
C-reactive protein
Middle Aged
medicine.disease
030104 developmental biology
ROC Curve
Case-Control Studies
Multivariate Analysis
biology.protein
Female
medicine.symptom
business
Cysteine-Rich Protein 61
Subjects
Details
- ISSN :
- 17520371
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....405659ee2966ceaddb5e2869f6167581