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[18F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the 'Negative' Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 1648, p 1648 (2021), Volume 10, Issue 8
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Background: The diagnostic performance of [18F]fluoro-ethylcholine-PET-CT&amp<br />4D-CT (FEC-PET&amp<br />4D-CT) to identify parathyroid adenomas (PA) was analyzed when ultrasound (US) or MIBI-Scan (MS) failed to localize. Postsurgical one year follow-up data are presented. Methods: Patients in whom US and MS delivered either incongruent or entirely negative findings were subjected to FEC-PET&amp<br />4D-CT and cases from July 2017 to June 2020 were analyzed, retrospectively. Cervical exploration with intraoperative PTH-monitoring (IO-PTH) was performed. Imaging results were correlated to intraoperative findings, and short term and one year postoperative follow-up data. Results: From July 2017 to June 2020 in 171 FEC-PET&amp<br />4D-CTs 159 (92.9%) PAs were suggested. 147 patients already had surgery, FEC-PET&amp<br />4D-CT accurately localized in 141<br />false neg. 4, false pos. 2, global sensitivity 0.97<br />accuracy 0.96, PPV 0.99. All of the 117 patients that already have completed their 12-month postoperative follow up had normal biochemical parameter, i.e., no signs of persisting disease. However, two cases may have a potential for recurrent disease, for a cure rate of at least 98.3%. Conclusion: FEC-PET&amp<br />4D-CT shows unprecedented results regarding the accuracy localizing PAs. The one-year-follow-up data demonstrate a high cure rate. We, therefore, suggest FEC-PET-CT as the relevant diagnostic tool for the localization of PAs when US fails to localize PA, especially after previous surgery to the neck.
- Subjects :
- Cure rate
medicine.medical_specialty
One year follow up
PET-CT
lcsh:Medicine
030209 endocrinology & metabolism
Article
hyperparathyroidism
03 medical and health sciences
0302 clinical medicine
parathyroid adenoma
Recurrent disease
Medicine
heterocyclic compounds
Parathyroid adenoma
FEC
Hyperparathyroidism
business.industry
Ultrasound
lcsh:R
FCH
General Medicine
medicine.disease
030220 oncology & carcinogenesis
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....405d0cb861762e51ef9fbadada0e4eff