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Mechanisms of acute cocaine toxicity

Authors :
Kennon Heard
Robert Palmer
Nancy R. Zahniser
Publication Year :
2008

Abstract

Patients with acute cocaine poisoning present with life-threatening symptoms involving several organ systems. While the effects of cocaine are myriad, they are the result of a limited number of cocaine-protein interactions, including monoamine transporter, neurotransmitter receptor and voltage-gated ion channels. These primary interactions trigger a cascade of events that ultimately produce the clinical effects. The purpose of this article is to review the primary interactions of cocaine and the effects that these interactions trigger. We also describe the progression of symptoms observed in cocaine poisoning as they relate to serum cocaine concentrations.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....4076772f8afb7a0619c213552cc5b8a7